{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:09:27Z","timestamp":1769735367994,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T00:00:00Z","timestamp":1653177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872457"],"award-info":[{"award-number":["81872457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972846"],"award-info":[{"award-number":["81972846"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Currently, the prognostic value of molecular subtypes in ductal carcinoma in situ (DCIS) remains unclear. In this study, we explored whether molecular subtypes could predict second breast events (SBEs) in patients after breast\u2010conserving surgery (BCS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2008 to December 2016, 291 DCIS patients treated with BCS were retrospectively analyzed. Patients were classified into four molecular subtypes: luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) overexpression, and triple\u2010negative breast cancer (TNBC). The SBE incidence was calculated by the competing risk model and compared by Gray's test. The disease\u2010free survival rates were estimated by the Kaplan\u2013Meier method and compared by the log\u2010rank test. Prognostic factors were evaluated by univariate and multivariate COX proportional hazards regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median follow\u2010up of 66\u00a0months, 12 SBEs were identified. The 5\u2010year overall SBE incidence of luminal A, luminal B, HER2 overexpression, and TNBC was 2.18%, 4.25%, 15.15%, and 0.00%, respectively. In the univariate analysis, the HER2 overexpression subtype was the predictor of overall (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005), in situ (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), and ipsilateral SBEs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). Patients with endocrine therapy were less likely to develop in situ SBEs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.039). Additionally, patients with closed (&lt;2\u00a0mm) or involved margins were related to a higher risk of contralateral SBEs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.029). In the multivariate analysis, the HER2 overexpression subtype remained of prognostic values for overall (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006), in situ (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.029), and ipsilateral SBEs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The molecular subtype, especially the HER2 overexpression subtype, was the independent prognostic factor for DCIS patients who underwent BCS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4651","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T16:38:18Z","timestamp":1653237498000},"page":"2755-2766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular subtypes predict second breast events of ductal carcinoma in situ after breast\u2010conserving 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