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The objective of this analysis was to evaluate the potential <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c effects of romidepsin. Patients with advanced malignancy received 4\u2010h infusions of 14\u00a0mg\/m<jats:sup>2<\/jats:sup> romidepsin on days 1, 8, and 15 of a 28\u2010day cycle. In cycle 2, a subset of patients received 1\u2010h infusions of 8\u201312\u00a0mg\/m<jats:sup>2<\/jats:sup> romidepsin. Patients were administered antiemetics before each romidepsin dose and electrolyte supplementation as needed. Electrocardiogram readings were performed prior to antiemetic administration, prior to romidepsin administration, and at specified time points over the subsequent 24\u00a0h. Romidepsin exposure and heart rate were also assessed. In the electrocardiogram\u2010evaluable population, 26 patients received romidepsin at 14\u00a0mg\/m<jats:sup>2<\/jats:sup> over 4\u00a0h. The maximum mean increases from the preantiemetic baseline for <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>cF and heart rate were 10.1\u00a0msec (upper 90% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 14.5\u00a0msec) and 18.2 beats per minute, respectively. No patient in this study had an absolute <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>cF value &gt;450\u00a0msec and only one patient had an increase from the preantiemetic baseline of &gt;60\u00a0msec. There was a mild reduction in the <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> interval and no meaningful changes in the <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> interval. Despite the use of <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\u2010prolonging antiemetics, treatment with romidepsin did not markedly prolong the <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval through 24\u00a0h. Increases in calculated <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c may have been exaggerated as a consequence of transient increases in heart rate.<\/jats:p>","DOI":"10.1002\/cam4.467","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T10:12:14Z","timestamp":1430129534000},"page":"1178-1185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Electrocardiographic effects of class 1 selective histone deacetylase inhibitor romidepsin"],"prefix":"10.1002","volume":"4","author":[{"given":"Philip T.","family":"Sager","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Balser","sequence":"additional","affiliation":[{"name":"Veristat, LLC Holliston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Wolfson","sequence":"additional","affiliation":[{"name":"Veristat, LLC Holliston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Nichols","sequence":"additional","affiliation":[{"name":"Jean Nichols LLC Swampscott Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Pilot","sequence":"additional","affiliation":[{"name":"Celgene Corporation Summit New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Jones","sequence":"additional","affiliation":[{"name":"Sarah Cannon Research Institute Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Burris","sequence":"additional","affiliation":[{"name":"Sarah Cannon Research Institute Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-3-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2133"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.313"},{"key":"e_1_2_7_5_1","unstructured":"2014.Istodax (romidepsin) [package insert].Celgene Corporation Summit NJ."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-7-11"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.9066"},{"key":"e_1_2_7_8_1","unstructured":"2011.Zolinza (vorinostat) [package insert].Merck & Co Whitehouse Station NJ."},{"key":"e_1_2_7_9_1","unstructured":"2014.Beleodaq (belinostat) [package insert].Spectrum Pharmaceuticals Irvine CA."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2005.s.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1715"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0376"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605726"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1786"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2689"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3816\/CGC.2006.n.018"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.167"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.23.16_suppl.3106"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.3.3.6253"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2095"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0109"},{"key":"e_1_2_7_22_1","first-page":"718","article-title":"Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms","volume":"8","author":"Sandor V.","year":"2002","journal-title":"Clin. 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