{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:11:57Z","timestamp":1773828717285,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772486"],"award-info":[{"award-number":["81772486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To reveal the correlation of dynamic serum tumor markers (STMs) and molecular features of epidermal growth factor receptor\u2010mutated (EGFR\u2010mutated) lung cancer during targeted therapy, we retrospectively reviewed 303 lung cancer patients who underwent dynamic STM tests [neuron\u2010specific enolase (NSE), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), the soluble fragment of cytokeratin 19 (CYFRA21\u20101), and squamous cell carcinoma antigen (SCC)] and circulating tumor DNA (ctDNA) testing with a panel covering 168 genes. At baseline, patients with EGFR mutation trended to have abnormal CEA, abnormal CA153, and normal SCC levels. Additionally, patients with Thr790Met (T790M) mutation were more likely to have abnormal CEA levels than patients without T790M mutation. Among patients with secondary resistance to EGFR tyrosine kinase inhibitors (TKI), the dynamic STMs showed a descending trend in the responsive stage and a rising trend in the resistant stage. However, the changing slopes differed between T790M subgroup and the non\u2010T790M subgroup in individual STMs. Our study demonstrated that the combination of baseline levels and variations of STMs (including the responsive stage and resistant stage) can be suggestive of secondary EGFR\u2010T790M mutation [area under the curve (AUC)\u00a0=\u00a00.897] and that changing trends of STMs (within 8\u00a0weeks after initiating the TKI therapy) can be potential predictors for the clearance of EGFR ctDNA [AUC\u00a0=\u00a00.871]. In conclusion, dynamic monitoring STMs can help to predict the molecular features of EGFR\u2010mutated lung cancer during targeted therapy.<\/jats:p>","DOI":"10.1002\/cam4.4676","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T08:23:18Z","timestamp":1652257398000},"page":"3115-3125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dynamic monitoring serum tumor markers to predict molecular features of <scp>EGFR<\/scp>\u2010mutated lung cancer during targeted therapy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-5986","authenticated-orcid":false,"given":"Zhuxing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Sun Yat\u2010sen University Cancer Centre, State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caichen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-2825","authenticated-orcid":false,"given":"Shan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-656X","authenticated-orcid":false,"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengrui","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanhong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-8192","authenticated-orcid":false,"given":"Jianxing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\/Oncology, China State Key Laboratory of Respiratory Disease &amp; National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31473-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2658"},{"key":"e_1_2_10_6_1","first-page":"6997","article-title":"BRAF and RAS mutations in human lung cancer and melanoma","volume":"62","author":"Brose MS","year":"2002","journal-title":"Cancer Research (Chicago, Ill)"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.84"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140611145"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.05.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.7"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.09.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2011.05.012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113205"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182745bcb"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20202"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3474-3"},{"key":"e_1_2_10_17_1","first-page":"550","article-title":"Serum CYFRA21\u20101 is correlated with the efficacy of epidermal growth factor receptor\u2010tyrosine kinase inhibitor in non\u2010small cell lung cancer patients harboring EGFR mutations","volume":"19","author":"Wang Q","year":"2016","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0603OC"},{"issue":"124","key":"e_1_2_10_19_1","first-page":"1","article-title":"Value of serum tumor markers for predicting EGFR mutations and positive ALK expression in 1089 Chinese non\u2010small\u2010cell lung cancer patients: a retrospective analysis","volume":"2020","author":"Wang S","year":"1990","journal-title":"Eur J Cancer"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0120"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.1718"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904554"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.1736"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1846"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2246"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30264-9"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.33.15_suppl.8001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713137"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612674"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/28.6.491"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2151"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2017.01.038"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04638-6"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.01.029"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31818dda85"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.05.014"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.11.1931"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01173"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.164"},{"key":"e_1_2_10_41_1","first-page":"307","article-title":"MUC\u20101 (CA 15\u20103 antigen) as a highly reliable predictor of response to EGFR inhibitors in patients with bronchioloalveolar carcinoma: an experience on 26 patients","volume":"22","author":"Bearz A","year":"2007","journal-title":"Int J Biol Markers"},{"key":"e_1_2_10_42_1","first-page":"832","article-title":"Clinical value of combined detection of serum tumor markers in lung cancer diagnosis","volume":"39","author":"Chen F","year":"2008","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.01.002"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S228301"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3107"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71180-5"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(00)00205-1"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2017.12.009"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4676","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4676","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T22:21:16Z","timestamp":1692310876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,11]]},"references-count":47,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/cam4.4676"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4676","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,11]]},"assertion":[{"value":"2021-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}