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However, how the immune system responds to GP remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We examined the dynamic changes of circulating immune cells and plasma cytokines in NPC patients administered with GP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>After GP administration, immunosuppressive myeloid cells, including CD11b+CD14+ monocytes, CD33+ myeloid cells, CD33+CD11+ myeloid cells, total MDSCs (CD33+CD11+HLA\u2010DR\u2212\/low), monocytic MDSCs, and granulocytic MDSCs decreased significantly. The regulatory T cells and B cells, two important suppressive lymphocyte subpopulations, also decreased. On the other hand, the levels of CD3+ T cells, total B cells, central memory CD4+ T cells, and pro\u2010inflammatory cytokines (including Interleukin [IL]\u20101\u03b2, IL\u20106, IL\u20102, IL\u20105, and IL\u20108) increased significantly after GP administration. Besides, GP chemotherapy did not weaken the cytotoxic activity and proliferative capacity of T cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results showed the immune modulation effect of GP induction chemotherapy in locoregionally advanced NPC, providing a solid basis for its combination with immunotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4705","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:54:33Z","timestamp":1648702473000},"page":"3437-3444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The immune modulation effects of gemcitabine plus cisplatin induction chemotherapy in nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"11","author":[{"given":"Xiao\u2010Min","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer 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