{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:21:38Z","timestamp":1784604098280,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcomas are rare diagnoses but are seen with relative frequency in adolescents and young adults and thus can present in pregnancy. We sought to study the administration of anthracyclines and\/or ifosfamide in pregnancy\u2010associated sarcomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We conducted a multi\u2010institutional retrospective study, identifying sarcoma patients who received anthracyclines and\/or ifosfamide during pregnancy. Chart review identified variables related to demographics, cancer diagnosis, therapies, and outcome of the patient and fetus. Wilcoxon rank\u2010sum test compared two independent samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 13 patients at seven institutions with sarcoma who received anthracyclines and\/or ifosfamide during pregnancy, including four bone sarcomas and nine soft tissue sarcomas diagnosed at a mean gestational age of 16.7\u00a0\u00b1\u00a05.9\u00a0weeks. Only nine patients had live births (9\/13, 69.2%), with mean gestational age of 30.8\u00a0\u00b1\u00a03.8\u00a0weeks at delivery. The four patients with pregnancy loss all received both doxorubicin and ifosfamide, with chemotherapy initiated at 15.5\u00a0weeks as compared with 21.3\u00a0weeks for those patients with live births (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this multi\u2010institutional study of sarcoma chemotherapy regimens administered during pregnancy, we found a high rate of fetal demise that was seen only in patients receiving both doxorubicin and ifosfamide and statistically more likely with chemotherapy initiation earlier in the second trimester. While limited by a small sample size, our study represents the largest study of sarcoma patients that received anthracyclines and\/or ifosfamide in pregnancy thus far reported and supports development of an international registry to study concerns raised by our study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4707","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T12:24:02Z","timestamp":1648470242000},"page":"3471-3478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pregnancy outcomes related to the treatment of sarcomas with anthracyclines and\/or ifosfamide during pregnancy"],"prefix":"10.1002","volume":"11","author":[{"given":"Devon","family":"Miller","sequence":"first","affiliation":[{"name":"University of Wisconsin\u2010Madison School of Medicine and Public Health  Madison Wisconsin 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