{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:47:27Z","timestamp":1769518047194,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T00:00:00Z","timestamp":1651968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502699"],"award-info":[{"award-number":["81502699"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anlotinib as a third\u2010line or beyond therapy for extensive\u2010stage small\u2010cell lung cancer (ES\u2010SCLC) was studied. This single\u2010arm phase II trial was to investigate the value of anlotinib plus platinum\u2010etoposide as first\u2010line treatment in ES SCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The primary endpoint was progression\u2010free survival (PFS) and objective response rate (ORR). The secondary endpoints included overall survival (OS), disease control rate (DCR), time to progression (TTP), duration of remission (DoR), and safety. The subgroups of preset liver metastasis and brain metastasis were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 35 ES\u2010SCLC patients, the median PFS, ORR, DCR, and OS were 8.02\u00a0months [95% confidence interval (CI): 6.90\u20139.66], 85.71% (95% CI: 69.74\u201395.19), 94.29% (95% CI: 80.84\u201399.30), and 15.87\u00a0months (95% CI: 10.38\u201318.89), respectively. The median PFS in the liver metastasis and brain metastasis subgroups was 7.33\u00a0months (95% CI: 4.76\u20139.69) and 7.34\u00a0months (95% CI: 5.68\u20139.20), respectively. The most common AEs with grade 3\u20134 were hand\u2013foot syndrome (17%), granulocytosis (17%), stomatitis (14%), hypertriglyceridemia (11%), hypercholesterolemia (11%), as well as nausea and vomiting (11%), and no grade 5 AEs were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anlotinib combined with platinum\u2010etoposide provided an effective and safe therapy for patients with ES\u2010SCLC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4736","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T12:09:12Z","timestamp":1652011752000},"page":"3563-3571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anlotinib plus platinum\u2010etoposide as a first\u2010line treatment for extensive\u2010stage small cell lung cancer: A single\u2010arm 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