{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:35:22Z","timestamp":1789011322819,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T00:00:00Z","timestamp":1651968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is not clear if all Americans have benefitted equally from the availability of chimeric antigen receptor T\u2010cell (CART) therapy. We aimed to evaluate if demographic differences existed among adult patients who received CART therapy and to assess predictors of CART treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of patients \u226518\u2009years who received CART therapy for non\u2010Hodgkin\u2019s lymphoma, acute lymphoblastic leukemia, and multiple myeloma in 2018 were evaluated in the National Inpatient Sample. Acute complications and inhospital mortality were compared between two groups of CART recipients: Whites and non\u2010Whites. Logistic regression analysis was used to evaluate the association between sociodemographic factors and inhospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1275 CART recipients that met inclusion criteria, there were 40.4% of females, 66.9% of Whites, Blacks (4.2%), Hispanics (13.3%), Asians or Pacific Islanders (4.2%), and Native Americans (1.3%). Up to 96.8% of CART procedures were performed in urban teaching hospitals, and 85.3% of CART recipients lived in metropolitan counties. Non\u2010Whites, compared to Whites, were younger at the time of CART therapy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The inhospital mortality rate was higher in non\u2010Whites, though not statistically significant (5.4% vs. 4.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.764). There were no differences in length of hospital stay, hospital charges, or rates of acute toxicities between the two race groups. We found no association between race and treatment outcomes. Gender, neurotoxicity, and Charlson Comorbidity Index were significant predictors of inhospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CART therapy recipients in the United States were more likely to be Whites and more likely to be residents of metropolitan areas. These observed demographic differences were not associated with treatment outcomes or inhospital mortalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4797","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T04:54:26Z","timestamp":1652072066000},"page":"4440-4448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Demographic differences among patients treated with chimeric antigen receptor <scp>T\u2010cell<\/scp> therapy in the United States"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3511-3956","authenticated-orcid":false,"given":"Josephine","family":"Emole","sequence":"first","affiliation":[{"name":"Stem Cell Transplantation and Cellular Therapy Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odunayo","family":"Lawal","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Program University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandra","family":"Lupak","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajoy","family":"Dias","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplantation Beth Israel Deaconess Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Shune","sequence":"additional","affiliation":[{"name":"Hematological Malignancies and Cellular Therapeutics The University of Kansas Health System  Kansas City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korede","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Public Health Program Adelphi University  Garden City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.25270\/jcp.2018.10.00039"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0977"},{"key":"e_1_2_9_5_1","unstructured":"WinstonW CMS. 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