{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:48:15Z","timestamp":1792118895650,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5U01CA209414"],"award-info":[{"award-number":["5U01CA209414"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA249096"],"award-info":[{"award-number":["R01CA249096"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary function can predict all\u2010cause mortality, and chronic obstructive pulmonary disease (COPD) is associated with worse overall survival (OS) in non\u2010small cell lung cancer (NSCLC) patients. Though pre\u2010operative lung function is predictive of in\u2010hospital mortality following lung cancer surgery, its predictive utility for long\u2010term survival is unclear. The prognostic role of commonly used spirometry tests in survival of lung cancer also remains uncertain. This study evaluates the role of spirometry at lung cancer diagnosis in predicting OS of NSCLC patients. This was a retrospective study using data from the Boston Lung Cancer Study on newly diagnosed NSCLC patients with spirometry tests performed before cancer therapy (<jats:italic>n<\/jats:italic>\u00a0=\u20092805). Spirometric test values, after being categorized using quartiles, were analyzed for association with OS using univariate and risk\u2010adjusted multiple regression models. Further, we analyzed OS by the status of COPD determined by spirometry, and, among those with COPD, by its stage defined by the Global Initiative for Chronic Obstructive Lung Disease criteria. Both univariate and multiple regression models demonstrated that lower quartiles of actual and percent predicted forced expiratory volume in 1\u2009second and forced vital capacity at lung cancer diagnosis were significantly associated with worse OS. Spirometry\u2010determined COPD, and more advanced stage of COPD at lung cancer diagnosis were associated with worse lung cancer OS. The findings provide evidence that a good pulmonary function at diagnosis may help improve OS in NSCLC patients.<\/jats:p>","DOI":"10.1002\/cam4.4808","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T08:03:28Z","timestamp":1652342608000},"page":"4796-4805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Spirometry at diagnosis and overall survival in <scp>non\u2010small<\/scp> cell lung cancer patients"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-1387","authenticated-orcid":false,"given":"Ting","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Brown","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Division, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lanuti","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin F.","family":"Gainor","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center and Department of Hematology &amp; Oncology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Christiani","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Pulmonary and Critical Care Division, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132017","author":"Howlader N","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0031"},{"key":"e_1_2_10_4_1","first-page":"9","article-title":"The International Association for the Study of Lung Cancer staging project: prognostic factors and pathologic TNM stage in surgically managed non\u2010small cell lung cancer","volume":"13","author":"Chansky K","year":"2010","journal-title":"Chinese J Lung 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