{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:45:44Z","timestamp":1790790344017,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mesenchymal chondrosarcoma (MCS) is an ultra\u2010rare sarcoma that follows a more aggressive course than conventional chondrosarcoma. This study evaluates prognostic factors, treatments (surgery, chemotherapy, and radiation), and outcomes in an Australian setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected demographics, clinicopathological variables, treatment characteristics, and survival status from patients with MCS registered on the national ACCORD sarcoma database. Outcomes include overall survival (OS) and progression\u2010free survival (PFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 22 patients with MCS between 2001\u20132022. Median age was 28 (range 10\u201359) years, 19 (86%) had localised disease at diagnosis of whom 16 had surgery (84%), 11 received radiation (58%), and 10 chemotherapy (53%). Ten (52%) developed recurrence and\/or metastases on follow\u2010up and three patients with initial metastatic disease received surgery, radiation, and chemotherapy. At a median follow\u2010up of 50.9\u00a0 (range 0.4\u2013210) months nine patients had died. The median OS was 104.1\u00a0months (95% CI 25.8\u2013182.3). There was improved OS for patients with localised disease who had surgical resection of the primary (<jats:italic>p<\/jats:italic>\u00a0=\u20090.003) and those with ECOG 0\u20131 compared to 2\u20133 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.023) on univariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates contemporary Australian treatment patterns of MCS. The role of chemotherapy for localised disease remains uncertain. Understanding treatment patterns and outcomes help support treatment decisions and design of trials for novel therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4849","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T09:41:07Z","timestamp":1653298867000},"page":"368-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mesenchymal chondrosarcoma: An Australian multi\u2010centre cohort study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5516-2619","authenticated-orcid":false,"given":"Madeleine C.","family":"Strach","sequence":"first","affiliation":[{"name":"Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"The University of Sydney Faculty of Medicine and Health  Sydney New South Wales 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