{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:25Z","timestamp":1786977325041,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Results from previous studies indicate that use of aspirin may improve colorectal cancer (CRC) survival. The aim of this study was to assess whether use of aspirin influences overall survival or CRC\u2010specific survival in an unselected cohort of patients diagnosed with CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was performed using the Colorectal Cancer Data Base Sweden (CRCBaSe), a mega\u2010linkage originating from the Swedish Colorectal Cancer Register, with additional linkages to other national health care registers. All patients diagnosed with primary CRC stage I\u2013III treated with curative surgery, aged 18\u201385\u2009years at diagnosis, from 2007 through 2016 were identified. Information on low\u2010dose aspirin use was extracted from the Swedish Prescribed Drug Register. Exposure was defined as dispensed prescription for at least 6\u00a0months. Aspirin exposure was analyzed at the time of surgery (yes\/no) and as a time\u2010varying exposure during follow\u2010up. Follow\u2010up was restricted to a maximum 6\u2009years, to model 5\u2010year survival. Cox regression models were fitted to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Adjustments were performed for sex, age, year of diagnosis, Charlson comorbidity index, hypertension, and ASA score as potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 32,195 patients diagnosed with CRC were included. 6764 (21%) were exposed to aspirin at the time of CRC surgery. The median time of follow\u2010up was 4.2\u2009years. Aspirin use at the time of surgery was not associated with all\u2010cause (adjusted HR\u00a0=\u00a01.03, 95% CI: 0.97\u20131.08) nor CRC\u2010specific mortality (adjusted HR\u00a0=\u00a00.99, 95% CI: 0.91\u20131.07). Aspirin use during follow\u2010up was associated with increased all\u2010cause (adjusted HR\u00a0=\u00a01.09, 95% CI: 1.04\u20131.15) but not CRC\u2010specific mortality (adjusted HR\u00a0=\u00a00.98, 95% CI: 0.91\u20131.06). A CRC\u2010specific effect associated with aspirin was noted from approximately 3\u2009years following surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large nation\u2010wide cohort study there was no convincing association between aspirin use after CRC and OS or CRC\u2010specific survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.4859","type":"journal-article","created":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T10:23:12Z","timestamp":1655634192000},"page":"315-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Low\u2010dose aspirin use and colorectal cancer survival in 32,195 patients\u2014A national cohort study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-0361","authenticated-orcid":false,"given":"Mehrnoosh","family":"Shahrivar","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-8183","authenticated-orcid":false,"given":"Caroline E.","family":"Weibull","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Ekstr\u00f6m Smedby","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvar","family":"Syk","sequence":"additional","affiliation":[{"name":"Department of Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Matthiessen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Nordenvall","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Pelvic Cancer, GI oncology and colorectal surgery unit Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Martling","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Pelvic Cancer, GI oncology and colorectal surgery unit Karolinska University Hospital  Stockholm 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