{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:10:29Z","timestamp":1773047429012,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19411960300"],"award-info":[{"award-number":["19411960300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12019113"],"award-info":[{"award-number":["SHDC12019113"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2019SY002"],"award-info":[{"award-number":["2019SY002"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to compare patterns of recurrence in 2009 FIGO Stage IB\u2010IIA (T<jats:sub>1b<\/jats:sub>N<jats:sub>0<\/jats:sub>M<jats:sub>0<\/jats:sub>\u2010T<jats:sub>2a<\/jats:sub>N<jats:sub>0<\/jats:sub>M<jats:sub>0<\/jats:sub>) cervical cancer patients with cN0 and cN1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The epidemiological and clinical data of 1352 patients who had undergone radical hysterectomy and systematic lymphadenectomy with cervical cancer treated from January 2008 to April 2019 at a tertiary teaching hospital were retrospectively collected. The primary aim was to discover the lymph node status\u2010dependent patterns and time of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumor recurrence and death were significantly less common in patients with cN0 than cN1. In addition, the length of time to recurrence (median 60\u2009months cN0 vs. 43\u2009months cN1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and death (median 84\u2009months cN0 vs. 68\u2009months cN1 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly longer in cN0 versus cN1 patients. The cumulative rate of relapse also showed a significant difference between cN0 and cN1 groups, especially the 1\u2010year relapse rate (2.14% vs. 10.78%). Of the patients who recurred, there was no difference in number of recurrent sites between cN0 and cN1 groups (solitary metastases:35.8% of cN0 and 35.6% of cN1; multiple metastases: 64.2% of cN0 and 64.4% of cN1). Similarly, there was no statistical difference in recurrence sites of cervical cancer between cN0 and cN1 groups based on three categories, (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.646). However, in the six categories, patients' vaginal vaults with negative lymph nodes were more prone to recurrence, while the distribution of other recurrence sites showed no significant difference between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a significant improvement of relapse\u2010free survival in the cN0 group, and the recurrence time of cN0 patients is significantly delayed than cN1 group. However, except for the risk of metastasis of the vaginal vault, the site of relapse remains similar.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4860","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T13:12:18Z","timestamp":1653570738000},"page":"306-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of recurrence patterns in cervical cancer patients with positive lymph nodes versus negative"],"prefix":"10.1002","volume":"12","author":[{"given":"Mei","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Wenzhou Medical University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1030-4601","authenticated-orcid":false,"given":"Haiyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University  Shanghai China"},{"name":"Department of Gynecology The First Affiliated Hospital of Wenzhou Medical University  Zhejiang 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