{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:49:02Z","timestamp":1755035342733,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contemporary therapies improve breast cancer (BC) outcomes. Yet, many of these therapies have been increasingly linked with serious cardiotoxicity, including reports of profound hypertension. Yet, the incidence, predictors, and impacts of these events are largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Leveraging two large U.S.\u2010based registries, the National Inpatient Sample (NIS) and the Food and Drug Administration Adverse Event Reporting System (FAERS) databases, we assessed the incidence, factors, and outcomes of hypertensive events among BC patients from 2007 to 2015. Differences in baseline characteristics, hypertension\u2010related discharges, and complications were examined over time. Further, we performed a disproportionality analysis using reporting\u2010odds\u2010ratios (ROR) to determine the association between individual BC drugs and hypertensive events. Utilizing an ROR cutoff of &gt;1.0, we quantified associations by drug\u2010class, and individual drugs with the likelihood of excess hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, there were 5,464,401\u2009BC\u2010admissions, of which 46,989 (0.8%) presented with hypertension. Hypertensive BC patients were older, and saw initially increased in\u2010hospital mortality, which equilibrated over time. The mean incidence of hypertension\u2010related admissions was 732 per 100,000 among BC patients, versus 96 per 100,000 among non\u2010cancer patients (RR 7.71, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Moreover, in FAERS, those with hypertension versus other BC\u2010treatment side\u2010effects were more frequently hospitalized (40.1% vs. 36.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and were most commonly associated with chemotherapy (45.9%). Outside of Eribulin (ROR 3.36; 95% CI 1.37\u20138.22), no specific drug was associated with a higher reporting of hypertension; however, collectively BC drugs were associated with a higher odds of hypertension (ROR 1.66; 95% CI 1.09\u20132.53).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BC therapies are associated with a substantial increase in limiting hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4862","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T06:04:54Z","timestamp":1653717894000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypertensive events after the initiation of contemporary cancer therapies for breast cancer control"],"prefix":"10.1002","volume":"12","author":[{"given":"Rebecca R.","family":"Carter","sequence":"first","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"},{"name":"The Center for the Advancement of Team Science, Analytics, and Systems Thinking (CATALYST) Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9467-6890","authenticated-orcid":false,"given":"Aaron P.","family":"Chum","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reynaldo","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avirup","family":"Guha","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"},{"name":"Harrington Heart and Vascular Institute Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit K.","family":"Dey","sequence":"additional","affiliation":[{"name":"National Heart Lung and Blood Institute  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-2222","authenticated-orcid":false,"given":"Raquel","family":"Reinbolt","sequence":"additional","affiliation":[{"name":"Solove Research Institute The Ohio State University Comprehensive Cancer Center \u2013 James Cancer Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prince","family":"Otchere","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oduro","family":"Oppong\u2010Nkrumah","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Lustberg","sequence":"additional","affiliation":[{"name":"Solove Research Institute The Ohio State University Comprehensive Cancer Center \u2013 James Cancer Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Addison","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology Ohio State University  Columbus Ohio USA"},{"name":"Cancer Control Program, Department of Medicine Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000556"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31674-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.4976"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.9129"},{"key":"e_1_2_12_7_1","unstructured":"HerceptinFDALabel. 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