{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:05:26Z","timestamp":1783019126221,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous metastases in pancreatic cancer (PC) are rare. Herein, we evaluate the clinical, genomic, and other descriptors of patients with PC and cutaneous metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Institutional databases were queried, and clinical history, demographics, PC cutaneous metastasis details, and overall survival (OS) from cutaneous metastasis diagnosis were abstracted. OS was estimated using Kaplan\u2013Meier methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients were identified, and median age (Q1\u2013Q3, IQR) of PC diagnosis was 66.0 (59.3\u201372.3, 12.9)\u00a0years. Most patients had Stage IV disease at diagnosis (<jats:italic>n<\/jats:italic>\u00a0=\u200926, 65%). The most common location of the primary tumor was the tail of the pancreas (<jats:italic>n<\/jats:italic>\u00a0=\u200917, 43%). The most common cutaneous metastasis site was the abdomen (<jats:italic>n<\/jats:italic>\u00a0=\u200931, 78%), with umbilical lesions occurring in 74% (<jats:italic>n<\/jats:italic>\u00a0=\u200923) of abdominal lesions. The median OS (95% CI) was 11.4\u00a0months (7.0, 20.4). Twenty\u2010three patients had umbilical metastases (58%), and 17 patients had non\u2010umbilical metastases (43%). The median OS (95% CI) was 13.7 (7.0, 28.7) months in patients with umbilical metastases and 8.9 (4.1, Not reached) months in patients with non\u2010umbilical metastases (<jats:italic>p<\/jats:italic>\u00a0=\u20090.1). Sixteen of 40 (40%) patients underwent somatic testing, and findings were consistent with known profiles. Germline testing in 12 (30%) patients identified pathogenic variants in patients: <jats:italic>CHEK2<\/jats:italic>, <jats:italic>BRCA1,<\/jats:italic> and <jats:italic>ATM.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cutaneous metastases from PC most frequently arise from a pancreas tail primary site and most frequently occur in the umbilicus. Cutaneous metastases may generally be categorized as umbilical or non\u2010umbilical metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4916","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T07:04:58Z","timestamp":1654499098000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0271-1880","authenticated-orcid":false,"given":"Lilly","family":"Gu","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paras P.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-051X","authenticated-orcid":false,"given":"Devika","family":"Rao","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Rotemberg","sequence":"additional","affiliation":[{"name":"Dermatology Service Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinela","family":"Capanu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Memorial Sloan Kettering  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Memorial Sloan Kettering  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Memorial Sloan Kettering  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlie S.","family":"Sigel","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus J.","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Boyce","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Library Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Gordon","sequence":"additional","affiliation":[{"name":"Dermatology Service Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-9199","authenticated-orcid":false,"given":"Eileen M.","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine  New York New York USA"},{"name":"Gastrointestinal Oncology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"David M. Rubenstein Center for Pancreatic Cancer, MSK  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1166"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13027"},{"key":"e_1_2_12_4_1","first-page":"241","article-title":"Pancreas cancer. I. Duct adenocarcinoma. 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