{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:19:33Z","timestamp":1790605173423,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>ADH1B<\/jats:italic>\n                      rs1229984 and\n                      <jats:italic>ALDH2<\/jats:italic>\n                      rs671 are the specifically prevalent functional variants in the East Asians. These variants, which result in a dramatic change in enzyme activity, are highly associated with alcohol\u2010related disorders and cancer. Previous studies focusing on the additive and synergic effects of the variants are few and inconsistent. The aim of the research was to evaluate the associations of\n                      <jats:italic>ADH1B<\/jats:italic>\n                      rs1229984 and\n                      <jats:italic>ALDH2<\/jats:italic>\n                      rs671 with the risks of alcohol\u2010related disorder and cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cohort study enrolled 42,665 participants from the Taiwan Precision Medicine Initiative database, including 19,522 and 20,534,\n                      <jats:italic>ADH1B<\/jats:italic>\n                      and\n                      <jats:italic>ALDH2<\/jats:italic>\n                      carriers, respectively. The associations between the two variants and cancer risk were analyzed by univariable and multivariable logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the noncarriers, the\n                      <jats:italic>ADH1B<\/jats:italic>\n                      rs1229984 variant had a stronger effect on alcohol\u2010related disorders and was related to an increased risk of alcohol\u2010related cancers. The CC genotype of\n                      <jats:italic>ADH1B<\/jats:italic>\n                      rs1229984 was significantly associated with cancer of the larynx, pharynx, and nasal cavities [odds ratio (OR)\u00a0=\u00a01.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0009], cancer of the pancreas (OR\u00a0=\u00a01.66,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.018), and cancer of the esophagus (OR\u00a0=\u00a04.10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Participants who carried the rs1229984 TC\/CC and rs671 GG genotypes were at higher risk of esophageal cancer (OR\u00a0=\u00a03.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The risk of esophageal cancer was increased by 381% (OR\u00a0=\u00a04.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in those carrying the rs1229984 TC\/CC and rs671 GA\/AA genotypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      rs1229984 and rs671 are common and functionally important genetic variants in the Taiwanese population. Our findings provide strong evidence of additive and synergic risks of\n                      <jats:italic>ADH1B<\/jats:italic>\n                      and\n                      <jats:italic>ALDH2<\/jats:italic>\n                      variants for alcohol\u2010related disorders and cancer. The results suggested that are reduction in alcohol consumption should be advised as a preventive measure for high\u2010risk patients carrying\n                      <jats:italic>ADH1B<\/jats:italic>\n                      rs1229984 C or the\n                      <jats:italic>ALDH2<\/jats:italic>\n                      rs671 A allele.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.4920","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T02:55:27Z","timestamp":1654570527000},"page":"747-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Impacts of\n                    <scp>\n                      <i>ADH1B<\/i>\n                    <\/scp>\n                    rs1229984 and\n                    <scp>\n                      <i>ALDH2<\/i>\n                    <\/scp>\n                    rs671 polymorphisms on risks of alcohol\u2010related disorder and cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Ting\u2010Gang","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Psychiatry Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Psychology Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Ting","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Hung","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Public Health, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Institute of Genomics and Bioinformatics National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8345-5304","authenticated-orcid":false,"given":"I\u2010Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"HannahR MaxR.Alcohol consumption. 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