{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:59:19Z","timestamp":1776099559466,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the effects of oral administration of magnesium\u2010L\u2010threonate, a novel magnesium compound, on the analgesic effect of opioids in patients with advanced cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective, randomized, double\u2010blind trial at a tertiary hospital in Shanghai, China. Eligible cancer patients who took opioids orally were assigned randomly to receive L\u2010TAMS capsules (1.5\u00a0g or 2.0\u00a0g according to weight) or a placebo (starch capsules). The primary outcome was the increase in the daily oral dose of morphine in each of the two groups, measured at 7, 14, 21, 30, 60, and 90\u2009days during this trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 116 patients from the oncology and pain departments, including inpatients and outpatients, were screened; 83 were enrolled. The increases in daily morphine doses began to differ from day 30 (L\u2010TAMS group 9.85\u2009mg\/d vs. Placebo group 20.49\u2009mg\/d, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); the differences persisted on day 60 (L\u2010TAMS group 15.96\u2009mg\/d vs. Placebo group 29.06\u2009mg\/d, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and on day 90 (L\u2010TAMS group 21.20\u2009mg\/d vs. Placebo group 40.44\u2009mg\/d, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>L\u2010TAMS outperforms a placebo in enhancing the analgesic effect of opioids and reducing the necessary opioid dosage. Moreover, L\u2010TAMS can significantly relieve opioid\u2010induced constipation. These advantages may be beneficial to patients with advanced cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4922","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T04:23:32Z","timestamp":1674793412000},"page":"4343-4351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oral application of magnesium\u2010L\u2010threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients\u2014A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-9955","authenticated-orcid":false,"given":"Siyin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pain Medicine Xinhua Hospital affiliated to Shanghai Jiaotong University, School of Medicine  Shanghai 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