{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:39:27Z","timestamp":1767065967908,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary gastric T\u2010cell lymphoma (PG\u2010TCL) is a rare hematological malignancy with few data reported. The objective of this study is to investigate the epidemiology, clinical characteristics, and survivals of PG\u2010TCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 164 patients with PG\u2010TCL from 1975 to 2016 extracted from the Surveillance, Epidemiology, and End Results Program (SEER) database were analyzed. Kaplan\u2013Meier method was applied to plot overall survival (OS) and cancer\u2010specific survival (CSS). The prognostic factors of OS and CSS were explored by Cox proportional hazard regression. Nomograms were constructed to predict survival possibilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The age\u2010adjusted incidence rate of PG\u2010TCL was 0.0091 per 100,000 person\u2010years and increased with age. The median age at onset was 65\u2009years old with male predominance. The major histological type was peripheral T\u2010cell lymphoma, NOS (63.4%). The 1\u2010, 2\u2010, and 5\u2010year OS were 45.5%, 34.7%, and 23.5%, respectively while the 1\u2010, 2\u2010, and 5\u2010year CSS were 47.4%, 37.3%, and 29.6%, respectively. Multivariate Cox analysis demonstrated that age at diagnosis, use of chemotherapy, and radiotherapy were the independent prognostic factors for OS. Chemotherapy combined with radiotherapy could significantly improve patients' OS compared with chemotherapy alone. Moreover, age at diagnosis and use of chemotherapy were also the independent prognostic factors for CSS. Nomograms for PG\u2010TCL were developed to predict 1\u2010, 2\u2010, and 5\u2010year OS possibilities. The predictability of nomograms was verified by high concordance index and good agreement with the predicted value in calibration plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PG\u2010TCL is a rare neoplasm with low incidence. Patients with PG\u2010TCL generally exhibited poor prognosis. Use of chemotherapy plus radiotherapy was associated with favorable OS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4936","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T05:15:31Z","timestamp":1655183731000},"page":"84-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The epidemiology and prognosis of patients with primary gastric T\u2010cell lymphoma in the <scp>SEER<\/scp> program"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-215X","authenticated-orcid":false,"given":"Minyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Hematology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Hematology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meisi","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Sichuan Provincial Acupuncture School  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengping","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hematology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Hematology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghui","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Hematology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004921319"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<693::AID-CNCR2820420241>3.0.CO;2-J"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800701)46:1<215::AID-CNCR2820460136>3.0.CO;2-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90081-N"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i1.5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i6.697"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"193","article-title":"Primary gastric diffuse large B\u2010cell lymphoma: prognostic factors in the Immuno\u2010oncology therapeutics era","volume":"37","author":"Bai Z","year":"2020","journal-title":"Turk J Haematol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2021.106716"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i35.5932"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5993-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0612-6"},{"issue":"48","key":"e_1_2_10_13_1","first-page":"1737","article-title":"Clinical and pathological features in T\u2010cell gastric lymphoma associated with human T\u2010cell leukemia virus type 1 (HTLV\u20101) in comparison with B\u2010cell gastric lymphoma","volume":"49","author":"Ishigami S","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970715)80:2<292::AID-CNCR18>3.0.CO;2-P"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.01.018"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.031"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03430.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2741"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.07.020"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14777"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12471"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-358"},{"issue":"4","key":"e_1_2_10_23_1","first-page":"273","article-title":"Treatment modalities in primary gastric lymphoma: the effect of rituximab and surgical treatment. 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