{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:58:53Z","timestamp":1765886333346,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2020\u201012\u20106"],"award-info":[{"award-number":["320.6750.2020\u201012\u20106"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The shortest distance between the superior mesenteric artery (SMA) or superior mesenteric vein (SMV) and the tumor margin was combined with preoperative serum carbohydrate antigen (CA) 19\u20109 and lymph node ratio (LNR) to evaluate joint effects on long\u2010term survival and liver metastasis in patients with pancreatic head cancer after radical surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 149 patients who underwent pancreaticoduodenectomy for pancreatic head cancer at Harbin Medical University Tumor Hospital from May 2011 to March 2021. The preoperative serum CA 19\u20109 level and LNR were combined with the SMA or SMV distance. The joint association between long\u2010term survival and postoperative liver metastasis was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the receiver operating characteristic curve of postoperative liver metastasis or long\u2010term survival, the optimal cut\u2010off values of SMV distance were 3.1 and 0.7\u2009mm, respectively, whereas the optimal cut\u2010off value of SMA distance was 10.25\u2009mm. The univariate model identified the liver metastasis score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as a negative factor for postoperative liver metastasis of pancreatic head carcinoma. The SMV distance (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), SMA distance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), LNR score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and survival score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were negatively correlated with long\u2010term survival after pancreatic head cancer. The multivariate model highlighted SMA distance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), survival score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and LNR score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as independent risk factors for long\u2010term survival in pancreatic head cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver metastasis score may be an independent predictor of postoperative liver metastasis in patients with pancreatic head cancer. Survival and LNR scores may be independent predictors of long\u2010term postoperative survival in patients with pancreatic head cancer. However, the LNR score appears to improve long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4957","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T10:45:40Z","timestamp":1657709140000},"page":"1064-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prediction scores of postoperative liver metastasis and long\u2010term survival of pancreatic head cancer based on the distance between the mesenteric vessels and tumor, preoperative serum carbohydrate antigen 19\u20109 level, and lymph node metastasis rate"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-7730","authenticated-orcid":false,"given":"Dan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaona","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-220X","authenticated-orcid":false,"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaige","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinshuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yisheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital  Harbin Heilongjiang P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i43.4846"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.08.008"},{"issue":"5","key":"e_1_2_13_5_1","first-page":"1","article-title":"Effect of postoperative major complications on prognosis after pancreatectomy for pancreatic cancer: a retrospective review","volume":"47","author":"Watanabe Y","year":"2016","journal-title":"Surg Today"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-015-1206-3"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-015-1120-8"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-013-2408-x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2021.01.014"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5515-6"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.03.020"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-018-0824-9"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0510-0"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12801"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13264"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6274-8"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.10.217"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-020-02065-w"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11328"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481808400130"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57930-x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188409"},{"issue":"12","key":"e_1_2_13_23_1","first-page":"4329","article-title":"Prognostic value of the metastatic lymph node ratio in patients with pancreatic cancer","volume":"12","author":"He C","year":"2019","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4957","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T13:46:30Z","timestamp":1692452790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,13]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/cam4.4957"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4957","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2022,7,13]]},"assertion":[{"value":"2022-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}