{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:33:59Z","timestamp":1767857639482,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004095","name":"Kyowa Hakko Kirin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004169","name":"Meiji Seika Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004169","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018036","name":"Nippon Shinyaku","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007132","name":"Otsuka Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002975","name":"Dainippon Sumitomo Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acquired erythrocytosis can be classified into polycythemia vera (PV) and non\u2010neoplastic erythrocytosis (NNE). The vast majority of PV patients harbor <jats:italic>JAK2<\/jats:italic> mutations, but differentiating <jats:italic>JAK2<\/jats:italic> mutation\u2010negative PV from NNE is challenging due to a lack of definitive molecular markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the clinical features of 121 patients with erythrocytosis of which 47 (38.8%) were JAK2 mutation\u2010positive and also fulfilled the diagnostic criteria for PV, and 67 (55.4%) JAK2 mutation\u2010negative erythrocytosis patients who were diagnosed as NNE. Diagnosis was strictly based on driver mutation analysis and central pathology review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No <jats:italic>JAK2<\/jats:italic> mutation\u2010negative PV patients were found in our cohort. The NNE group showed significantly younger (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) age with higher frequency of smoking (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), alcohol consumption (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and diabetes mellitus (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), whereas the PV group (<jats:italic>n<\/jats:italic>\u00a0=\u00a047) showed significantly higher white blood cell count, platelet count, and lactate dehydrogenase (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Although serum erythropoietin (EPO) levels were significantly higher in NNE compared to PV (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), approximately 40% of the NNE patients had EPO levels below the lower range of normal, fulfilling a minor diagnostic criterion of PV and raising the possibility of PV misdiagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low EPO levels in <jats:italic>JAK2<\/jats:italic> mutation\u2010negative erythrocytosis may not be a reliable diagnostic criterion for distinguishing PV from NNE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4958","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T07:44:37Z","timestamp":1656661477000},"page":"1079-1089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical features of acquired erythrocytosis: Low levels of serum erythropoietin in a subset of non\u2010neoplastic erythrocytosis patients"],"prefix":"10.1002","volume":"12","author":[{"given":"Yosuke","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-5000","authenticated-orcid":false,"given":"Marito","family":"Araki","sequence":"additional","affiliation":[{"name":"Laboratory for the Development of Therapies Against MPN Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Advanced Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1081-0130","authenticated-orcid":false,"given":"Soji","family":"Morishita","sequence":"additional","affiliation":[{"name":"Laboratory for the Development of Therapies Against MPN Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Advanced Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-5957","authenticated-orcid":false,"given":"Misa","family":"Imai","sequence":"additional","affiliation":[{"name":"Laboratory for the Development of Therapies Against MPN Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-1871","authenticated-orcid":false,"given":"Yoko","family":"Edahiro","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Laboratory for the Development of Therapies Against MPN Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Advanced Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pathology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-4211","authenticated-orcid":false,"given":"Tomonori","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Laboratory for the Development of Therapies Against MPN Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Advanced Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Shirane","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Laboratory for the Development of Therapies Against MPN Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Advanced Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-9814","authenticated-orcid":false,"given":"Yoshinori","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Laboratory for the Development of Therapies Against MPN Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Advanced Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-7737","authenticated-orcid":false,"given":"Hajime","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Cell Therapy and Transfusion Medicine Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-9126","authenticated-orcid":false,"given":"Norio","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Laboratory for the Development of Therapies Against MPN Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Advanced Hematology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"PharmaEssentia Japan KK  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01290-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-695940"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.04.006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01116-z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.12703\/r\/10-29"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.139"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1567-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104958"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.115113"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-018-2421-7"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14763"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200001000-00007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1592-z"},{"issue":"10","key":"e_1_2_12_16_1","first-page":"1194","article-title":"Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis","volume":"89","author":"Mossuz P","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17848"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00463-x"},{"issue":"6","key":"e_1_2_12_19_1","first-page":"703","article-title":"Effects of long\u2010term ethanol administration on the kidneys, bones and muscles of mice","volume":"33","author":"Sakurama K","year":"1998","journal-title":"Nihon Arukoru Yakubutsu Igakkai Zasshi"},{"issue":"11","key":"e_1_2_12_20_1","first-page":"158s","article-title":"The pathogenesis and significance of the urinary alcohol cycle in rats fed ethanol intragastrically","volume":"29","author":"French SW","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.01.005"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2019.102355"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2019.1483"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4958","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T13:50:54Z","timestamp":1692453054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/cam4.4958"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4958","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2022-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}