{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:17:26Z","timestamp":1791688646087,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71904109"],"award-info":[{"award-number":["71904109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["ZR2019PG0060"],"award-info":[{"award-number":["ZR2019PG0060"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["ZR2020KH029"],"award-info":[{"award-number":["ZR2020KH029"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>This study investigated the natural history of esophageal squamous cell carcinoma (ESCC) in rural Chinese. We sought to help provide more data to support ESCC screenings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was based on an existing Screening Program in Feicheng, China. Esophageal precancerous lesions were identified in 1753 cases, diagnosed from esophageal cancer screenings from 2006 to 2016. We followed up with them through endoscopic screening until October 1, 2017. Pathology results from various grades of precancerous lesions were recorded and the annual transition probabilities and incidence density of ESCC were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As of October 1, 2017, a total of 4055.8 person\u2010years has been observed. The ESCC incidence density of mild, moderate, and severe dysplasia (SD) was 0.17, 0.79, and 1.77 per 100 person\u2010years, respectively. The median follow\u2010up time of mild, moderate, and SD was 3.5, 2.3, and 2.2\u2009years, respectively. The annual transition probability of mild, moderate, and SD to the next pathological level was 0.025, 0.038, and 0.016, respectively. The ESCC incidence density of males was 2.6 times higher than females (0.58 vs. 0.22), and the older age group (56\u201369 age group) had a ESCC incidence density 1.2 times higher than the younger group (40\u201355 age group) (0.45 vs. 0.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The higher the grade of precancerous lesions, the higher the incidence density of ESCC. Screening of esophageal cancer in males and the elderly should be strengthened. It is recommended to reinforce follow\u2010up management for untreated patients with SD\/carcinoma in situ. For patients with mild and moderate dysplasia in high\u2010risk rural Chinese populations, endoscopic follow\u2010up intervals can be appropriately adjusted to once every 2\u2009years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.4965","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:01:00Z","timestamp":1656583260000},"page":"1791-1800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Progression of precancerous lesions of esophageal squamous cell carcinomas in a high\u2010risk, rural Chinese population"],"prefix":"10.1002","volume":"12","author":[{"given":"Dongqing","family":"Gao","sequence":"first","affiliation":[{"name":"Jining NO.1 People's Hospital  Jining China"},{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-6260","authenticated-orcid":false,"given":"Peipei","family":"Lu","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3494-5806","authenticated-orcid":false,"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cancer Center, People's Hospital of Feicheng  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2529-7918","authenticated-orcid":false,"given":"Jinhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-1804","authenticated-orcid":false,"given":"Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Weifang Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cancer Center, People's Hospital of Feicheng  Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253\u20103766.2019.01.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308124"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29227"},{"issue":"5","key":"e_1_2_11_7_1","first-page":"398","article-title":"Analysis of the esophageal cancer mortality in 2004\u20132005 and its trends during last 30\u2009years in China","volume":"44","author":"Wei WQ","year":"2010","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940415)73:8<2027::AID-CNCR2820730803>3.0.CO;2-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940915)74:6<1686::AID-CNCR2820740608>3.0.CO;2-V"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.046631"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1347"},{"key":"e_1_2_11_12_1","volume-title":"Technology Scheme for Cancer Early Detection and Treatment","author":"Cancer Early Detection, and Treatment Expert Group, Bureau of Disease Control, Ministry of Health","year":"2011"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.0423"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000640"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.046631"},{"key":"e_1_2_11_16_1","volume-title":"Cancer Early Detection and Treatment Program Report 2012\/2013","author":"Bureau of Disease Prevention and Control, National Health and Family Planning Commission","year":"2013"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980715)83:2<220::AID-CNCR4>3.0.CO;2-U"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X9301300409"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/110241500750008277"},{"issue":"5","key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"AB552","DOI":"10.1016\/j.gie.2016.03.1131","article-title":"Tu1144 dysplastic burden in Barrett's esophagus with low\u2010grade dysplasia is associated with progression to high\u2010grade dysplasia or adenocarcinoma[J]","volume":"83","author":"Kahn A","year":"2016","journal-title":"Gastrointest Endosc"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19900615)65:12<2731::aid\u2010cncr2820651222>3.0.co;2\u20101"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9612854"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20616"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S167311"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000\u20109604.2019.02.10"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.4965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4965","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.4965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T13:46:59Z","timestamp":1692452819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.4965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/cam4.4965"],"URL":"https:\/\/doi.org\/10.1002\/cam4.4965","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]},"assertion":[{"value":"2022-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}