{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:05:54Z","timestamp":1792112754756,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["PR\u2010PRU\u20101217\u201021601"],"award-info":[{"award-number":["PR\u2010PRU\u20101217\u201021601"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is uncertainty about overdiagnosis in mammography screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We aimed to estimate the effect of screening on breast cancer incidence and overdiagnosis in the NHS Breast Screening Programme in England. The study included 57,493 cases and 105,653 controls, with cases defined as women diagnosed at ages 47\u201389 with primary breast cancer, invasive or ductal carcinoma in situ, in 2010 or 2011. Where possible, two controls were selected per case, matched on date of birth and screening area.<\/jats:p><jats:p>Conditional logistic regression was used to estimate the effect of screening on breast cancer risk, with adjustment for potential self\u2010selection bias. Results were combined with national incidence data to estimate absolute rates of overdiagnosis. Overdiagnosis was calculated as the cumulative excess of cancers diagnosed in the age group 50\u201377 in a woman attending three\u2010yearly screening between ages 50 and 70 compared with a woman attending no screens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The estimated number of cases overdiagnosed in women attending all screens in the programme was 679.3 per 100,000 without adjustment for self\u2010selection bias and 261.2 per 100,000 with adjustment. These corresponded to an estimated 9.5% of screen\u2010detected cancers overdiagnosed without adjustment and 3.7% with adjustment for self\u2010selection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The NHS Breast Screening Programme in England confers at worst modest levels of overdiagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5004","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:01:11Z","timestamp":1658188871000},"page":"1878-1887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A case\u2013control study to evaluate the impact of the breast screening programme on breast cancer incidence in England"],"prefix":"10.1002","volume":"12","author":[{"given":"Oleg","family":"Blyuss","sequence":"first","affiliation":[{"name":"Centre for Prevention, Detection, and Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Dibden","sequence":"additional","affiliation":[{"name":"Centre for Prevention, Detection, and Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie J.","family":"Massat","sequence":"additional","affiliation":[{"name":"Centre for Prevention, Detection, and Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8767-8364","authenticated-orcid":false,"given":"Dharmishta","family":"Parmar","sequence":"additional","affiliation":[{"name":"Centre for Prevention, Detection, and Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7420-7512","authenticated-orcid":false,"given":"Jack","family":"Cuzick","sequence":"additional","affiliation":[{"name":"Centre for Prevention, Detection, and Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Centre for Prevention, Detection, and Diagnosis, Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sasieni","sequence":"additional","affiliation":[{"name":"School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Cancer Research UK.Breast Cancer Incidence (Invasive) Statistics.https:\/\/www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/breast\u2010cancer\/incidence\u2010invasive."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr932"},{"key":"e_1_2_10_4_1","unstructured":"Cancer Research UK.Breast Cancer Morality Statistics.https:\/\/www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/breast\u2010cancer\/mortality."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70380-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61611-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.06.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2012.012082"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/096914130301100106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29124"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-596"},{"key":"e_1_2_10_12_1","unstructured":"Office for National Statistics. Cancer Registration Statistics England 2011. National Statistics 2012.https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/conditionsanddiseases\/datasets\/cancerregistrationstatisticscancerregistrationstatisticsengland"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0803"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0969141313510293"},{"key":"e_1_2_10_15_1","volume-title":"England 2018\u201319","author":"Breast Screening Programme","year":"2020"},{"key":"e_1_2_10_16_1","volume-title":"R Project for Statistical Computing","author":"R Development Core Team","year":"2019"},{"key":"e_1_2_10_17_1","volume-title":"Stata Statistical Software: Release 16","author":"StataCorp","year":"2019"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018171539"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.415"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-2125"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0969141313495190"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38764.572569.7C"},{"key":"e_1_2_10_23_1","volume-title":"England 2020\u201321","author":"NHS Breast Screening Programme","year":"2022"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.06.006"},{"key":"e_1_2_10_25_1","unstructured":"https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/lifeexpectancies\/datasets\/nationallifetablesunitedkingdomreferencetables"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.5004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T13:51:57Z","timestamp":1692453117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/cam4.5004"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5004","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]},"assertion":[{"value":"2022-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}