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The underlying mechanism involves the soft nature of tumor stem cells that allows better uptake of vesicles, and the entry of drug\u2010carrying vesicles into lysosomes and facilitation of lysosomal movement toward the nucleus to deliver drugs to the nucleus. Drug\u2010loaded vesicles have unique advantages, such as low immunogenicity, homing targeting ability, and the ability to break through the physiological barrier to tumor therapy. Tumor\u2010derived drug\u2010delivery vesicles have entered clinical trials for the treatment of malignant pleural effusions. 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