{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:06:22Z","timestamp":1785528382788,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor\u2010size\u2010stratified analysis on the prognosis of uterine sarcoma is insufficient. This study aimed to establish the tumor\u2010size\u2010stratified nomograms to predict the 3\u2010 and 5\u2010year overall survival (OS) of patients with uterine sarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data analyzed in this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. We collected data from patients with uterine sarcoma diagnosed between 2004 and 2015. According to the median tumor size of 7.8\u00a0cm, the enrolled patients were divided into two tumor size (TS) groups: TS &lt;7.8\u00a0cm and TS \u22657.8\u00a0cm. Patients in each group were randomly divided into the training and validation cohorts with a ratio of 7:3. Chi\u2010square test was used to compare differences between categorical variables. Multivariate Cox regression models were used to identify significant predictors. We calculated the concordance index (C\u2010index) and the area under the receiver operating characteristics curve (AUC) to validate the nomograms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with TS &lt;7.8\u00a0cm group, TS \u22657.8\u00a0cm group had more patients of 45\u201364\u2009years group, higher black race prevalence, higher proportion of myometrium tumor, higher stage, and higher grade; In the TS &lt;7.8\u00a0cm training cohort, six variables (age, race, marital status, tumor primary site, stage, and grade) were identified as significantly associated with OS in multivariate analysis. However in the TS \u22657.8\u00a0cm training cohort, only four variables (surgery on primary site, tumor size, stage, and grade) were significantly identified; The C\u2010index of two nomograms were 0.80 and 0.73 in training cohorts, respectively, and the AUC values for 3\u2010 and 5\u2010year OS predictions in training cohorts were all above 0.80. Similar results were observed in validation cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study found that the significant prognostic factors were different between two tumor size groups of uterine sarcoma patients. The tumor\u2010size\u2010stratified nomograms, which we constructed and validated, might be useful to predict the probability of survival for patients with uterine sarcoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5014","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T11:45:12Z","timestamp":1657971912000},"page":"1339-1349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and validation of tumor\u2010size\u2010stratified prognostic nomograms for patients with uterine sarcoma: A <scp>SEER<\/scp> database analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-2559","authenticated-orcid":false,"given":"Shiyu","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kekui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract11040103"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S117754"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71116-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12067"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-4578"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.922739"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2019-0674"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0469"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619845602"},{"key":"e_1_2_10_13_1","unstructured":"National Cancer Institute.Surveillance Epidemiology and End Results Program (SEER)https:\/\/seer.cancer.gov\/. 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