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Although several treatment methods are available, their efficacy is short term or accompanied by unacceptable complications. In the past two decades, botulinum toxin type A (<jats:styled-content style=\"fixed-case\">BTXA<\/jats:styled-content>) has been widely used to treat <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>. Although several systematic reviews have been reported recently, they were conflicting and with obvious deficiencies. Thus, we performed an objectively systematic review to determine whether <jats:styled-content style=\"fixed-case\">BTXA<\/jats:styled-content> is an effective and safe treatment for <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>. A literature retrieval covering PubMed, Web of Science, Ovid, Embase and Cochrane library was performed on 16 January, 2015. Proportion meta\u2010analysis and corresponding 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were performed to evaluate the efficacy and safety of <jats:styled-content style=\"fixed-case\">BXTA<\/jats:styled-content> in treatment of <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>. A total of 499 records were retrieved and 22 articles with 23 studies were included after scrutiny by two independent authors. Statistical analyses regarding the effective rate, incidence of complications were used to estimate the efficacy and safety of <jats:styled-content style=\"fixed-case\">BTXA<\/jats:styled-content>. Our results suggested that the effective rate of <jats:styled-content style=\"fixed-case\">BTXA<\/jats:styled-content> for treatment of <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> is 98.5% (95% CI\u00a0=\u00a00.971\u20130.994) and the incidence of complication is 3.6% (95% CI\u00a0=\u00a00.017\u20130.061). In conclusion, our study supports that <jats:styled-content style=\"fixed-case\">BTXA<\/jats:styled-content> produces meaningful benefits on the treatment of patients with <jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content>. However, owing to lack of strong evidence, future studies with well\u2010designed inclusion criteria and multicenter randomized controlled trials are needed to give more credible evidence, if possible.<\/jats:p>","DOI":"10.1002\/cam4.504","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T01:08:10Z","timestamp":1440637690000},"page":"1639-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Efficacy and safety of botulinum toxin type A for treatment of Frey's syndrome: evidence from 22 published articles"],"prefix":"10.1002","volume":"4","author":[{"given":"Shang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Sheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Stomatology Capital Medical University Pinggu Teaching Hospital  Beijing 101200 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Feng","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Gang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880110115"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199711000-00013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016485809134736"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(96)90344-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100138769"},{"key":"e_1_2_8_7_1","first-page":"194","article-title":"Memoire sur l'obliteration du canal de Stenon","volume":"23","author":"Baillarger J. 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