{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T22:05:10Z","timestamp":1766181910738,"version":"3.40.5"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M690037"],"award-info":[{"award-number":["2021M690037"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103409"],"award-info":[{"award-number":["82103409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intraductal papillary mucinous neoplasms (IPMNs) are the precursor lesions of pancreatic cancers, requiring active surgical intervention during cancer development. However, the current criteria for predicting malignant IPMNs remain challenging and limited. Hence, this study aimed to assess the discriminatory performance of circulating cytokines, including TNF\u2010\u03b1, IL\u20102R, IL\u20106, and IL\u20108, then build a novel predictive model to improve the diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 131 retrospective (from March 2016 to December 2019) and 53 prospective (from March 2020 to January 2021) patients who were histologically confirmed as IPMNs were consecutively collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The circulating levels of TNF\u2010\u03b1, IL\u20102R, IL\u20106, and IL\u20108 were significantly elevated in malignant IPMNs, and were verified as independent factors for malignant IPMNs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Then, a novel score, the circulating cytokine score (CCS), was calculated and demonstrated as an independent predictive indicator with a higher area under the curve (AUC) than each cytokine alone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Besides the CCS, two high\u2010risk stigmata features, the presence of solid component (PSC), and main pancreatic duct (MPD) dilation \u226510\u2009mm were also demonstrated as independent indicators for predicting malignant IPMNs. Finally, a novel nomogram incorporating the CCS and these two high\u2010risk stigmata features presented a remarkable diagnostic performance, both in the training and validation cohorts with AUCs of 0.928 and 0.873, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CCS can be considered a novel independent predictive indicator for malignant IPMNs. Additionally, the formulated nomogram model integrating the CCS, PSC, and MPD \u226510\u2009mm can be a valuable and promising tool for predicting the malignant transformation of IPMNs during long\u2010term follow\u2010ups to assist in timely and accurate surgical decisions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5051","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T12:28:37Z","timestamp":1658665717000},"page":"3919-3930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circulating cytokines allow for identification of malignant intraductal papillary mucinous neoplasms of the pancreas"],"prefix":"10.1002","volume":"12","author":[{"given":"Ning","family":"Pu","sequence":"first","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiangda","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanlin","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Department of Pathology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengxiang","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantao","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenchuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0710-4403","authenticated-orcid":false,"given":"Wenhui","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of General Surgery Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Cancer Center, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15841-8"},{"key":"e_1_2_12_4_1","article-title":"Current status and future perspectives of clinical research in pancreatic cancer: Establishment of evidence by science","author":"Pu N","year":"2021","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.4690"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000155055.14238.25"},{"key":"e_1_2_12_7_1","unstructured":"MalageladaJ GudaN GohML et al.Pancreatic cystic lesions \u2010 World Gastroenterology Organisation 2019. 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