{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:05:07Z","timestamp":1784257507708,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903252"],"award-info":[{"award-number":["81903252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872551"],"award-info":[{"award-number":["81872551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the role of prophylactic cranial irradiation (PCI) in limited\u2010stage small\u2010cell lung cancer (LS\u2010SCLC) according to tumor response in the magnetic resonance imaging (MRI) era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated patients with LS\u2010SCLC without brain metastases (BMs) on MRI who achieved either complete response (CR) or partial response (PR) after initial chemoradiotherapy at our center from 2006 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study comprised 116 patients (median age, 58\u2009years; men, 92; women, 24). After initial chemoradiotherapy, 53 patients achieved CR, while 63 patients achieved PR. Eighty\u2010three patients received PCI. Patients who received PCI had better overall survival (OS, 5\u2010year: 52.5% vs. 35.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012) and progression\u2010free survival (PFS, 5\u2010year: 45.0% vs. 28.2%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and a lower incidence of BMs (5\u2010year: 18.3% vs. 39.4%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.010). In the subgroup analysis, PCI improved OS (5\u2010year: 67.8% vs. 46.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) and PFS (5\u2010year: 65.2% vs. 35.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) and decreased BM risk (5\u2010year: 12.1% vs. 52.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) for patients with CR. However, PCI had no benefit (5\u2010year OS: 40.5% vs. 35.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.763; 5\u2010year BMs: 24.6% vs. 31.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.561) for patients with PR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tumor response remained an important factor for selecting patients for PCI in the MRI era. PCI should be recommended for patients with LS\u2010SCLC who achieve CR after initial thoracic chemoradiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5082","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T14:12:40Z","timestamp":1658931160000},"page":"2484-2492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prophylactic cranial irradiation for limited\u2010stage small\u2010cell lung cancer in the magnetic resonance imaging era"],"prefix":"10.1002","volume":"12","author":[{"given":"Lihua","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Affiliated Hospital of Jining Medical University  Jining Shandong 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