{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:32:07Z","timestamp":1768689127906,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008603","name":"Cancer Institute, University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008603","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple primary melanoma (MPM) is known to be associated with familial melanoma. However, the association between MPM and other personal and familial cancers is not well documented. The objective of this study was to evaluate the association between MPM and personal history of other cancers or cancer history among first\u2010degree relatives (FDRs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective case\u2013control study including cases with gender\u2010matched MPM and single primary melanoma (SPM) at a 1:2 ratio from the University of Pittsburgh Cancer Institute Melanoma Center Biological Sample and Nevus Bank. The associations between MPM and other cancers were evaluated using univariable and multivariable logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 378 patients (44.2% men; median age 52\u2009years) were enrolled, including 252 with SPM and 126 with MPM. In comparison to patients with SPM, patients with MPM were more likely to have squamous cell carcinoma (odds ratio [OR] 1.95, 95% confidence interval [CI] 1.001\u20133.79, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047) and prostate cancer (OR 2.72, 95% CI 1.07\u20137.01, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.034). FDRs of patients with MPM had higher prevalence of melanoma (OR 2.37, 95% CI 1.31\u20134.28, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) and prostate cancer (OR 2.92, 95% CI 1.47\u20136.14, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) but not other cancers. In multivariable analysis, the association remained significant between MPM and squamous cell carcinoma (OR 2.18, 95% CI 1.08\u20134.39, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.028), prostate cancer (OR 2.85, 95% CI 1.09\u20137.54, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.032), FDR history of melanoma (OR 2.37, 95% CI 1.31\u20134.29, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), and FDR history of prostate cancer (OR 3.26, 95% CI 1.59\u20136.83, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with MPM have a higher prevalence of personal and FDR histories of nonmelanoma skin cancers and prostate cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5088","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T04:09:22Z","timestamp":1659758962000},"page":"2474-2483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multiple primary melanoma in association with other personal and familial cancers"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9843-3925","authenticated-orcid":false,"given":"Xi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilit","family":"Karapetyan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology; University of Pittsburgh Medical Center Hillman Cancer Center  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