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We examined the prospective associations of total n\u20103 PUFA, marine\u2010derived n\u20103 PUFA [combined eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA)], and alpha\u2010linolenic acid (ALA) as plant\u2010derived n\u20103 PUFA with the risk of CRC by subsite in the Japan Collaborative Cohort Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The participants completed a self\u2010administered food frequency questionnaire and had no prior history of CRC. Cox proportional hazards model was used to determine the associations between n\u20103 PUFAs intake and CRC risk overall and by anatomical subsite.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the median 13.8\u2010year follow\u2010up period, 699 of the 42,536 participants aged 40\u201379\u2009years developed incident CRC. An inverse association was found between dietary ALA intake and the risk of distal colon cancer; the multivariable hazard ratios and 95% confidence intervals for the highest quartiles (Q4) were 0.41 (0.21\u20130.81; <jats:italic>p<\/jats:italic> trend\u00a0=\u00a00.01) compared with the lowest quartiles (Q1). Marine n\u20103 PUFA intake was not associated with CRC risk in the overall or anatomical subsite\u2010specific analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that higher ALA intake may be beneficial for lowering the risk of distal colon cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5098","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:59:43Z","timestamp":1660125583000},"page":"4690-4700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between dietary intake of n\u20103 polyunsaturated fatty acids and risk of colorectal cancer in the Japanese population: The Japan Collaborative Cohort Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8507-3641","authenticated-orcid":false,"given":"Ayako","family":"Kato","sequence":"first","affiliation":[{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Okada","sequence":"additional","affiliation":[{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab S.","family":"Eshak","sequence":"additional","affiliation":[{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine  Osaka Japan"},{"name":"Department of Public Health, Faculty of Medicine Minia University  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9241-7289","authenticated-orcid":false,"given":"Hiroyasu","family":"Iso","sequence":"additional","affiliation":[{"name":"Public Health, Department of Social Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Tamakoshi","sequence":"additional","affiliation":[{"name":"Department of Public Health Hokkaido University Faculty of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the JACC Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32802"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310912"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2021.291"},{"key":"e_1_2_10_6_1","unstructured":"Foundation for Promotion of Cancer Research.2021.Cancer statistics in Japan 2021. 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