{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:04:17Z","timestamp":1772118257484,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the association between assisted reproductive technology (ART) use and childhood cancer subtype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We deployed a cross\u2010sectional survey of 1701 parents of children with cancer about their ART use, demographics, and gestational and perinatal factors. Multivariable logistic regression modeled the association between ART use, birthweight and multiple gestation status with childhood cancer, by subtype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ART use was highest among children with osteosarcoma relative to children with other cancer types, and this association was statistically significant in multivariable models (OR\u00a0=\u00a04.4; 95% CI\u00a0=\u00a01.7\u201311.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0020). ART use was also elevated among children with hepatoblastoma, but this relationship appeared to be due to the strong associations between ART use and lower birthweight in our sample. No specific ART modality appeared to drive these associations. In univariate models, multiple gestation was associated with a 2.7\u2010fold increased odds of hepatoblastoma (OR\u00a0=\u00a02.71; 95% CI\u00a0=\u00a01.14\u20136.42;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) and a 1.6\u2010fold increased odds of neuroblastoma (OR\u00a0=\u00a01.62; 95% CI\u00a0=\u00a01.03\u20132.54;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03), but these associations were not retained in multivariable models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Associations between ART use and hepatoblastoma risk may be attributable to birthweight, a known hepatoblastoma risk factor. ART use may also be associated with osteosarcoma, independent of birthweight, an association not previously observed in studies limited to cancers diagnosed before adolescence. Evaluating long\u2010term health outcomes in children conceived by ART, throughout adolescence and potentially into adulthood, appears warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.5114","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T07:14:38Z","timestamp":1659683678000},"page":"3410-3418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assisted reproductive technology and association with childhood cancer subtypes"],"prefix":"10.1002","volume":"12","author":[{"given":"Natalie B.","family":"Gulrajani","sequence":"first","affiliation":[{"name":"Children's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine  Durham North Carolina 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Department of Pediatrics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian H.","family":"Hurst","sequence":"additional","affiliation":[{"name":"Children's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Landi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Preston Robert Tisch Brain Tumor Center Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherika N.","family":"Hill","sequence":"additional","affiliation":[{"name":"Children's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine  Durham North Carolina USA"},{"name":"Frank Porter Graham Child Development Institute The University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-9981","authenticated-orcid":false,"given":"Kyle M.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Children's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine  Durham North Carolina USA"},{"name":"Department of Neurosurgery and Preston Robert Tisch Brain Tumor Center Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Cancer Institute Duke University School of Medicine  Durham North Carolina 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