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Small nucleolar RNAs (snoRNAs) are tumor\u2010specific biological markers, but there are few studies on the role of snoRNAs in DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Survival\u2010related snoRNAs were selected to construct a specific snoRNA\u2010based signature via computational analyses (Cox regression and independent prognostic analyses) to predict the prognosis of DLBCL patients. To assist in clinical applications, a nomogram was built by combining the risk model and other independent prognostic factors. Pathway analysis, gene ontology analysis, transcription factor enrichment, protein\u2013protein interactions, and single nucleotide variant analysis were used to explore the potential biological mechanisms of co\u2010expressed genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve prognosis\u2010correlated snoRNAs were selected from the DLBCL patient cohort of microarray profiles, and a three\u2010snoRNA signature consisting of SNORD1A, SNORA60, and SNORA66 was constructed. DLBCL patients could be divided into high\u2010risk and low\u2010risk cohorts using the risk model, and the high\u2010risk group and activated B cell\u2010like (ABC) type DLBCL were linked with disappointing survival. In addition, SNORD1A co\u2010expressed genes were inseparably linked to the biological functions of the ribosome and mitochondria. Potential transcriptional regulatory networks have also been identified. <jats:italic>MYC<\/jats:italic> and <jats:italic>RPL10A<\/jats:italic> were the most mutated SNORD1A co\u2010expressed genes in DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Put together, our findings explored the potential biological effects of snoRNAs in DLBCL, and provided a new predictor for DLBCL prediction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5115","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T07:14:43Z","timestamp":1660634083000},"page":"3812-3829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Identification of three small nucleolar <scp>RNAs<\/scp> (<scp>snoRNAs<\/scp>) as potential prognostic markers in diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Mei\u2010wei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Oncology First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi Zhuang Autonomous Region P. 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