{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:15:47Z","timestamp":1791656147210,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lenvatinib is approved for the treatment of patients with metastatic or recurrent hepatocellular carcinoma (HCC); however, clinical outcomes of lenvatinib therapy in patients with post\u2010liver transplantation (LT) HCC recurrence remain unclear. We investigated the efficacy and safety of lenvatinib in patients with post\u2010LT HCC recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multinational, multicenter, retrospective study included 45 patients with recurrent HCC after LT who received lenvatinib at six institutions in three countries (Korea, Italy, and Hong Kong) from June 2017 to October 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the time of lenvatinib initiation, 95.6% (<jats:italic>n<\/jats:italic>\u00a0=\u00a043) of patients had Child\u2013Pugh A status, and 35 (77.8%) and 10 (22.2%) participants were classified as having albumin\u2013bilirubin (ALBI) grades 1 and 2, respectively. The objective response rate was 20.0%. With a median follow\u2010up duration of 12.9\u00a0months (95% confidence interval [CI]: 11.2\u201314.7), the median progression\u2010free survival and overall survival (OS) were 7.6 (95% CI: 5.3\u20139.8) months, and 14.5 (95% CI: 0.8\u201328.2) months, respectively. Patients with ALBI grade 1 showed significantly better OS (52.3\u00a0months, [95% CI: not assessable]) than patients with ALBI grade 2 (11.1\u00a0months [95% CI: 0.0\u201330.4\u00a0months], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). The most common adverse events were hypertension (<jats:italic>n<\/jats:italic>\u00a0=\u00a025, 55.6%), fatigue (<jats:italic>n<\/jats:italic>\u00a0=\u00a017, 37.8%), and anorexia (<jats:italic>n<\/jats:italic>\u00a0=\u00a014, 31.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lenvatinib showed consistent efficacy and toxicity profiles in patients with post\u2010LT HCC recurrence that were comparable to those reported from previous studies among non\u2010LT HCC patients. The baseline ALBI grade correlated with better OS in post\u2010LT lenvatinib\u2010treated patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5123","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T04:35:10Z","timestamp":1659760510000},"page":"2572-2579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy and safety of lenvatinib in patients with recurrent hepatocellular carcinoma after liver transplantation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5168-8197","authenticated-orcid":false,"given":"Kyunghye","family":"Bang","sequence":"first","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine Chung\u2010Ang University Gwangmyeong Hospital  Gwangmyeong Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Casadei\u2010Gardini","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Vita\u2010Salute San Raffaele University, IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1451-8455","authenticated-orcid":false,"given":"Changhoon","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Iavarone","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Hee","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook Ryun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung\u2010Don","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010In","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hwan","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil\u2010Chun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul\u2010Soo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok\u2010Bog","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi\u2010Won","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mazzarelli","sequence":"additional","affiliation":[{"name":"Hepatology and Gastro\u2010Enterology Unit ASST Ospedale Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Alimenti","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Chan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Translational Oncology Department of Clinical Oncology, Sir YK Pao Centre for Cancer, The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"De Giorgio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Liver Transplantation, Papa Giovanni XXIII Hospital  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baek\u2010Yeol","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy308"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20128"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03689.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i39.11185"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.01.001"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2020.19877"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30207-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1263-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1354"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2020.06.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v10.i11.297"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13184584"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15581"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508901"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112608"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13718"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512239"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00604-5"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01307"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0585-1"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq055"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.27.15_suppl.e15579"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.09.022"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01540.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002955"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11070952"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480256"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365993"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15014"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.5123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T08:22:18Z","timestamp":1732522938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cam4.5123"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5123","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"assertion":[{"value":"2022-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}