{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:19:54Z","timestamp":1761059994302,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","doi-asserted-by":"crossref","award":["26460482"],"award-info":[{"award-number":["26460482"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>The cancer stroma, including cancer\u2010associated fibroblasts (CAF<\/jats:styled-content>s), is known to contribute to cancer cell progression and metastasis, suggesting that functional proteins expressed specifically in CAF<\/jats:styled-content>s might be candidate molecular targets for cancer treatment. The purpose of the present study was to explore the possibility of using TEM<\/jats:styled-content>1 (tumor endothelial marker 1), which is known to be expressed in several types of mesenchymal cells, as a molecular target by examining the impact of TEM<\/jats:styled-content>1 expression on clinicopathological factors in gastric cancer patients. A total of 945 consecutive patients with gastric cancer who underwent surgery at the National Cancer Center Hospital East between January 2003 and July 2007 were examined using a tissue microarray approach. TEM<\/jats:styled-content>1 expression in CAF<\/jats:styled-content>s or vessel\u2010associated cells was determined using immunohistochemical staining. Three items (CAF<\/jats:styled-content>\u2010TEM<\/jats:styled-content>1\u2010positivity, CAF<\/jats:styled-content>\u2010TEM<\/jats:styled-content>1\u2010intensity, and vessel\u2010TEM<\/jats:styled-content>1\u2010intensity) were then examined to determine the correlations between the TEM<\/jats:styled-content>1 expression status and the recurrence\u2010free survival (RFS<\/jats:styled-content>), overall survival (OS<\/jats:styled-content>), cancer\u2010related survival (COS<\/jats:styled-content>), and other clinicopathological factors. Significant correlations between CAF<\/jats:styled-content>\u2010TEM<\/jats:styled-content>1\u2010positivity or CAF<\/jats:styled-content>\u2010TEM<\/jats:styled-content>1\u2010intensity and RFS<\/jats:styled-content>, OS<\/jats:styled-content>, or COS<\/jats:styled-content> were observed (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001, Kaplan\u2013Meier curves); however, no significant correlation between vessel\u2010TEM<\/jats:styled-content>1\u2010intensity and RFS<\/jats:styled-content>, OS<\/jats:styled-content>, or COS<\/jats:styled-content> was observed. A univariate analysis showed that CAF<\/jats:styled-content>\u2010TEM<\/jats:styled-content>1\u2010positivity and CAF<\/jats:styled-content>\u2010TEM<\/jats:styled-content>1\u2010intensity were each correlated with a scirrhous subtype, tumor depth, nodal status, distant metastasis, serosal invasion, lymphatic or venous vessel infiltrations, and pTMN<\/jats:styled-content> stage. This study suggests that the inhibition of TEM<\/jats:styled-content>1 expression specifically in the CAF<\/jats:styled-content>s of gastric carcinoma might represent a new strategy for the treatment of gastric cancer.<\/jats:p>","DOI":"10.1002\/cam4.515","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T05:21:55Z","timestamp":1441344115000},"page":"1667-1678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["TEM<\/scp>1 expression in cancer\u2010associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer"],"prefix":"10.1002","volume":"4","author":[{"given":"Satoshi","family":"Fujii","sequence":"first","affiliation":[{"name":"Pathology Division Research Center for Innovative Oncology National Cancer Center at Kashiwa National Cancer Center Hospital East 6\u20105\u20101 Kashiwanoha Kashiwa Chiba 277\u20108577 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