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Patients were divided among those who maintained response (group 1, <jats:italic>n<\/jats:italic>\u00a0=\u2009123) and those who lost major molecular response (group 2, <jats:italic>n<\/jats:italic>\u00a0=\u200945). Mean BCR::ABL1 RNA levels 1\u2009month after discontinuation were higher in group 2 than in group 1 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.0005) and the difference was more evident 2\u2009months after stop (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001). The same trend was found both for imatinib and 2G\u2010TKIs. A receiver operating characteristic (ROC) analysis to determine a threshold value of BCR::ABL1 at 1\u2009month after discontinuation identified a cut\u2010off value of 0.0051%, with 92.2% specificity, 31.7% sensitivity and a likelihood ratio of 4.087.<\/jats:p>","DOI":"10.1002\/cam4.5158","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T07:20:42Z","timestamp":1665213642000},"page":"3180-3184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["BCR::ABL1 levels at first month after TKI discontinuation predict subsequent maintenance of treatment\u2010free remission: A study from the \u201cGRUPPO TRIVENETO LMC\u201d"],"prefix":"10.1002","volume":"12","author":[{"given":"Sara","family":"Di Giusto","sequence":"first","affiliation":[{"name":"Division of Hematology and BMT Azienda Sanitaria Universitaria Friuli Centrale  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Toffoletti","sequence":"additional","affiliation":[{"name":"Division of Hematology and BMT Azienda Sanitaria Universitaria Friuli Centrale  Udine Italy"},{"name":"Department of Medical Area University of Udine  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-1686","authenticated-orcid":false,"given":"Massimiliano","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Binotto","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology and Clinical Immunology University of Padua  Paduva Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Miggiano","sequence":"additional","affiliation":[{"name":"Department of Hematology San Bortolo Hospital  Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Calistri","sequence":"additional","affiliation":[{"name":"Hematology Unit Ca\u2019 Foncello Hospital  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Stulle","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Sanitaria Universitaria Giuliano\u2010Isontina  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ermacora","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliera S. 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