{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:48:32Z","timestamp":1787676512765,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["817780218"],"award-info":[{"award-number":["817780218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC1299"],"award-info":[{"award-number":["2022NSFSC1299"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite the availability of new agents, elderly patients with multiple myeloma (MM) usually present with poor outcomes due to the heterogeneity of disease conditions, especially immune deficiency. Regulatory B cells (Bregs) can be involved in immune defects by exerting immune regulatory functions in MM. In order to provide more evidence\u2010based practice for the elderly MM, the study established and assessed a stratified therapeutic model with studies on Bregs for Chinese Elderly Multiple Myeloma in 2021 (CEMM2021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open\u2010label, non\u2010interventional, prospective study in the real world, 159 newly diagnosed MM (NDMM) patients over <jats:italic>65\u2009years old<\/jats:italic> were sequentially recruited and bone marrow aspirates prior to treatment were obtained to detect the ratios of Bregs by flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the CEMM2021 model, 147 patients had received at least one cycle of induction therapy, including bortezomib\/dexamethasone (Bd) (<jats:italic>n<\/jats:italic>\u00a0=\u00a080), lenalidomide\/dexamethasone (Rd) (<jats:italic>n<\/jats:italic>\u00a0=\u00a027), Bd with a third agent X (Bd\u2009+\u2009X) (<jats:italic>n<\/jats:italic>\u00a0=\u00a027), and other regimens (<jats:italic>n<\/jats:italic>\u00a0=\u00a013). The proportions of patients achieving very good partial response or better were comparable among Bd, Bd\u2009+\u2009X, and Rd groups (41.9% vs. 54.5% vs. 44.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.472). Besides, the progression\u2010free survival (PFS) and overall survival (OS) were not significantly different among Rd, Bd, and Bd\u2009+\u2009X groups. Multivariable analysis showed that induction efficacy less than partial response (PR) were poor prognostic factors for PFS, while Revised\u2010International Staging System (R\u2010ISS) III and efficacy less than PR were poor prognostic factors for OS. This study also found that the ratios of bone marrow Bregs &lt;10% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.036) and SUVmax of PET\u2010CT scan &gt;4.2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.000) were closely correlated with OS in the elderly MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For the elderly NDMM, the CEMM2021 algorithm in our center might provide a valuable reference for the guidance of therapeutic strategies, with the combination of Bregs resulting in an effective and clinically meaningful prediction in contemporary treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5228","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T03:09:57Z","timestamp":1663729797000},"page":"3054-3067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A stratified therapeutic model incorporated with studies on regulatory B cells for elderly patients with newly diagnosed multiple myeloma"],"prefix":"10.1002","volume":"12","author":[{"given":"Wenjiao","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqing","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Department of Hematology Clinical Medical College &amp; Affiliated Hospital of Chengdu University, Chengdu University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-7550","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60493-1"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2016.11.004"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23731"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0539-0"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.07.006"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03640-y"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00440-4"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-615187"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.35"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-078071"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59266"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-19-0349"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0843"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12939"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.24"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00844"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.671904"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-361386"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.03.001"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0396"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.11.014"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17350"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04529-5"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402551"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817249"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-795047"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3511"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1950708"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-662627"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.0023"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.220657"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2698"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.4710"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.005"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.006"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0002"},{"issue":"5","key":"e_1_2_14_40_1","first-page":"480","article-title":"Guidelines for the diagnosis and management of multiple myeloma in China (2022 revision)","volume":"61","author":"Chinese Hematology Association; Chinese Society of Hematology","year":"2022","journal-title":"Zhonghua nei ke za zhi"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073587"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.05.026"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.5228","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T08:25:26Z","timestamp":1732523126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cam4.5228"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5228","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"assertion":[{"value":"2021-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}