{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:24:55Z","timestamp":1791829495660,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intraperitoneal paclitaxel is proved to be efficient for peritoneal metastasis of gastric cancer. It remains uncertain the efficacy and safety of the triplets regimen which combined intraperitoneal high\u2010dose paclitaxel with systemic SOX in gastric cancer patients with peritoneal metastasis. This study aimed to evaluate the efficacy and safety of intraperitoneal administration of high\u2010dose paclitaxel, intravenous oxaliplatin and S\u20101 in patients with peritoneal metastatic gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, prospective, single\u2010arm phase II study was conducted between January 2017 and May 2019 in West China Hospital, Sichuan University. Patients diagnosed with primary gastric cancer by histopathology and confirmed synchronous peritoneal metastasis were enrolled. This study aimed to evaluate efficacy and safety of intraperitoneal administration of high\u2010dose paclitaxel (80\u2009mg\/m<jats:sup>2<\/jats:sup>, d1), intravenous oxaliplatin (100\u2009mg\/m<jats:sup>2<\/jats:sup>, d1), and S\u20101 (80\u2009mg\/m<jats:sup>2<\/jats:sup>, d1\u201014) of patients. The primary endpoint was 1\u2010year overall survival rate, and the second endpoints were progression\u2010free survival (PFS), overall survival (OS), overall response rate (ORR), disease control rate (DCR) and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this single\u2010arm phase II clinical trial, 49 patients received SOX combined intraperitoneal high\u2010dose paclitaxel treatment. One\u2010year survival rate was 81.6% (95% CI, 68.6\u201390.0%). Median PFS and OS were 6.50\u2009months (95% CI, 2.89\u201310.11) and 16.9\u00a0months (95% CI, 13.58 to 20.22), respectively; ORR was 55.3% (95% CI, 41.3\u201368.6) and DCR was 76.6% (95% CI, 62.8\u201386.4). Thirteen patients underwent second laparoscopic detection, but only nine ultimately underwent radical gastrectomy. Subgroup analysis showed that sPCI \u226412 was a good index for a favorable prognosis. The most frequent grade 3\/4 toxicities were neutropenia (40.8%), anemia (22.4%), leukopenia (18.4%), nausea (14.3%), and vomiting (12.2%). None of the patients had any intraperitoneal catheter\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraperitoneal high\u2010dose paclitaxel with systemic SOX is an effective and tolerable first\u2010line treatment for patients with peritoneal metastatic gastric cancer and patients with sPCI\u226412 scores might be recommended crowd for this regimen as conversion therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5277","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T07:50:01Z","timestamp":1664178601000},"page":"4161-4169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Study of <scp>SOX<\/scp> combined with intraperitoneal high\u2010dose paclitaxel in gastric cancer with synchronous peritoneal metastasis: A phase <scp>II<\/scp> single\u2010arm clinical trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2645-1806","authenticated-orcid":false,"given":"Li","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-8245","authenticated-orcid":false,"given":"Weihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-6592","authenticated-orcid":false,"given":"Lu","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-4803","authenticated-orcid":false,"given":"Zihan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-5736","authenticated-orcid":false,"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-1341","authenticated-orcid":false,"given":"Hongfeng","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-5636","authenticated-orcid":false,"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-3190","authenticated-orcid":false,"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-3471","authenticated-orcid":false,"given":"Jiankun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-6938","authenticated-orcid":false,"given":"Meng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_9_3_1","article-title":"Chemotherapy for advanced gastric cancer","volume":"8","author":"Wagner AD","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-016-0660-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-020-01042-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-019-0349-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.v18i4.737"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.709234"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0062-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.5908"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073149"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.5.970"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp260"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-017-0710-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052985"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.12.2961"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28204"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.8613"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32557-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.8429"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1247-5_23"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(03)00037-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.03.008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-018-0856-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7800-2-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2020.20.e6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i30.6906"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.11.139"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.5277","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T16:56:22Z","timestamp":1747673782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cam4.5277"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5277","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]},"assertion":[{"value":"2021-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}