{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:38:00Z","timestamp":1775083080722,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900489"],"award-info":[{"award-number":["81900489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This retrospective study aimed to evaluate the factors influencing the accuracy of Endoscopic Ultrasonography (EUS) as a preoperative assessment for gastrointestinal tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 261 patients with 264 gastrointestinal tumors were enrolled in the study. The parameters of the gastrointestinal lesions examined under EUS and their pathology were recorded and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The accuracy of EUS for detecting intramucosal lesions and subepithelial lesions (SELs) were 83.6% and 91.4%, respectively. One hundred and ninety\u2010four (73.5%) lesions originated from the mucous layer, as determined by pre\u2010operation EUS examinations. The accuracy of EUS in predicting the correct T stage for intramucosal lesions in the gastric region, esophagus, and colorectum was 77%, 71.8%, and 84.6%, respectively. According to the Paris endoscopic classification, the distribution of macroscopic patterns was different between the EUS\u2010pathology conformity and nonconformity groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018). In the nonconformity group, 48.6% of erosive lesions were classified as 0\u2010IIc, 0\u2010IIa\u2009+\u2009IIc, 0\u2010IIc\u2009+\u2009IIa or 0\u2010III macroscopic patterns compared with 26% patients in the conformity group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.025). Univariate analyses demonstrated that ulcerative lesions (OR\u00a0=\u00a07.516, 95% Confidence Interval [CI] 2.574\u201321.952, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), location at the cardia of the stomach (OR\u00a0=\u00a03.619, 95%CI 1.076\u201312.168, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038), malignant tumor (OR\u00a0=\u00a02.920, 95%CI 1.339\u20136.368, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) were significantly associated with EUS inaccuracy. Multivariate logistic regression analyses showed that ulcer was an independent risk factor associated with EUS inaccuracy, with odds ratios of 5.094 (95% CI: 1.641\u201315.807, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggested that EUS is a reliable and easy\u2010to\u2010use diagnostic tool in decision\u2010making regarding appropriate endoscopic treatment for gastrointestinal tumors. However, the diagnostic accuracy of EUS appeared questionable in the presence of ulceration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5305","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T06:55:27Z","timestamp":1664520927000},"page":"4321-4331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The factors influencing the accuracy of pre\u2010operative endoscopic ultrasonography assessment in endoscopic treatments for gastrointestinal tumors"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0638-4741","authenticated-orcid":false,"given":"Yan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mudan","family":"Ren","sequence":"additional","affiliation":[{"name":"Department 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University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-1896","authenticated-orcid":false,"given":"Shuixiang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Xi'an Jiaotong University  Xi'an 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