{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:27:34Z","timestamp":1778261254749,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA172145"],"award-info":[{"award-number":["1R01CA172145"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["2R01CA226080"],"award-info":[{"award-number":["2R01CA226080"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cognitive impairment is a frequent adverse effect of cancer and its therapies. As neuropsychological assessment is not often standard of care for patients with non\u2010CNS disease, efficient, practical assessment tools are required to track cognition across the disease course. We examined cognitive functioning using a web\u2010based cognitive testing battery to determine if it could detect differences between patients with cancer and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 22 patients with multiple myeloma (MM) or non\u2010Hodgkin lymphoma (NHL) and 40 healthy controls (mean age\u00a0=\u00a056\u2009\u00b1\u200911\u2009years, 52% male). Participants completed the BrainCheck cognitive testing battery and online versions of select measures from the Patient Reported Outcome Measures Information System (PROMIS) during a video conference. MANOVA was used to compare BrainCheck and PROMIS scores between groups controlling for age and sex. An exploratory linear regression analysis was conducted within the cancer group to determine potential contributors to cognitive functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All participants except for one control completed the online assessment measures without difficulty. Compared to controls, the cancer group demonstrated significantly lower scores in objective and subjective cognitive function, physical functioning, and social role performance and elevated fatigue scores. Corticosteroid treatment, immunotherapy, lower physical functioning, lower income, and older age significantly contributed to lower cognitive function (adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u20090.925, <jats:italic>F<\/jats:italic>\u00a0=\u200919.63, <jats:italic>p<\/jats:italic>\u00a0=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Remote assessment of cognitive and psychosocial functioning is feasible with patients with cancer following treatments. The BrainCheck cognitive testing battery has the potential to detect differences in cognition between patients with cancer and controls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5331","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T05:20:10Z","timestamp":1665552010000},"page":"6068-6076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Remote assessment of cognitive dysfunction in hematologic malignancies using web\u2010based neuropsychological testing"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5547-1518","authenticated-orcid":false,"given":"Oscar Y.","family":"Franco\u2010Rocha","sequence":"first","affiliation":[{"name":"Brain Health Neuroscience Lab School of Nursing, University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misty L.","family":"Mahaffey","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Stanford Cancer Institute, Stanford Health Care  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Oncology Dell School of Medicine, University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-8014","authenticated-orcid":false,"given":"Shelli R.","family":"Kesler","sequence":"additional","affiliation":[{"name":"Brain Health Neuroscience Lab School of Nursing, University of Texas at Austin  Austin Texas USA"},{"name":"Department of Oncology Dell School of Medicine, University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13867"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951518000664"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/JNCI\/DJZ168"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-050817-084903"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.19.2335"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2020.1738213"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812756-8.00002-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-020-01155-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz410"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.5640"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.5674"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2015.07.006"},{"key":"e_1_2_10_14_1","unstructured":"National Cancer Institute.Cancer Stat Facts: Non\u2010Hodgkin Lymphoma. 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