{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:45:56Z","timestamp":1779889556295,"version":"3.53.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immunotherapy has exhibited efficacy in thymic carcinoma patients; however, there are insufficient data to confirm this efficacy in thymoma. The toxicity of immunotherapy also remains to be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The efficacy and safety of immunotherapy were analyzed in 11 thymoma patients who received PD\u20101 inhibitors according to a range of relevant indexes including the objective response rate (ORR), disease control rate (DCR), progression\u2010free survival (PFS), overall survival (OS), and immunotherapy\u2010related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PFS and OS rates for all patients were 12.8 and 56.5 months, respectively. No difference in efficacy was detected between monotherapy and combination therapy (PFS: 12.8 vs 2.2 months, P = 0.787; OS: 73.8 vs 56.5 months, P = 0.367). The ORRs and DCRs for all patients were 27.3% and 90.9%, respectively. The incidence of adverse events was 45.5% among the 11 thymoma patients, including immune\u2010related myocarditis (36.4%), immune\u2010related liver damage (18.2%), and myasthenia gravis (18.2%). In the whole cohort of patients, the rate of adverse events of grade 3 or higher was 36.4%. The rates of adverse events of grade 3 or 4 in B3\u2010type and non\u2010B3\u2010type thymoma patients were 0% and 62.5%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immunotherapy elicited a response in thymoma patients; however, more attention should be paid to the immune\u2010related adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5357","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T07:43:56Z","timestamp":1668671036000},"page":"5649-5655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of the efficacy and safety of immunotherapy in advanced thymoma patients"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-6084","authenticated-orcid":false,"given":"Yue","family":"Hao","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College of Zhejiang Chinese 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