{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:38:47Z","timestamp":1747147127296,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although various coronavirus disease 2019 (COVID\u201019) vaccines have been delivered to the public worldwide, data on cancer populations are limited. Vaccine hesitancy related to safety concerns is observed among cancer patients. We report the perception of COVID\u201019 vaccines and their safety profile after vaccination among cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Between April and November 2021, a multicenter survey was conducted on 318 patients treated in any hemato\u2010oncology outpatient clinic among three hospitals under the Korea University Medical Center. The medical records of the patients were reviewed to obtain detailed clinical and hematological toxicity data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A perception survey was conducted among 293 patients. Among them, 53.9% were concerned about developing vaccine\u2010related adverse events (VRAEs) and 23.5%, about negative effects on cancer treatment. During the study period, 255 and 186 patients participated in a safety survey after the first and second doses, respectively. After the first dose, 62% of patients reported VRAEs (2.4%, grade 3), whereas 48.9% reported VRAEs (2.7%, grade 3) after the second dose. For both doses, injection\u2010site pain and sore arm pain were the most common VRAEs, followed by myalgia, fatigue, and headache. No grade 4\/5 VRAEs were observed, and there were no differences in complete blood count after vaccination. Multivariate analysis revealed female sex, active cancer treatment, and mRNA vaccines as independent risk factors for VRAE development in cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite high levels of concern, COVID\u201019 vaccines were well tolerated by cancer patients, with a safety profile consistent with that of the general population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5400","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T06:44:51Z","timestamp":1668408291000},"page":"5558-5568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perception and safety analysis of COVID\u201019 vaccination in cancer patients: A multicenter, real\u2010world study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6578-7671","authenticated-orcid":false,"given":"Kyoungmin","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Hae","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Cheul","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hong","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Ji","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sang","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ah\u2010reum","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Anam Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Han","family":"Hyun","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Anam Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Anam Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jwa Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Anam Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Ji","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Anam Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soohyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Anam Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Anam Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2555-2333","authenticated-orcid":false,"given":"Yeul Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Anam Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Yoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Ansan Hospital Ansan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Ansan Hospital Ansan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Ryeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Ansan Hospital Ansan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa Jung","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Ansan Hospital Ansan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-3400","authenticated-orcid":false,"given":"Eun Joo","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine, Korea University College of Medicine Korea University Guro Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,13]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.WHO Coronavirus (COVID\u201019) Dashboard. 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