{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:59:13Z","timestamp":1771952353878,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0901400"],"award-info":[{"award-number":["2016YFC0901400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0901404"],"award-info":[{"award-number":["2016YFC0901404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current evidence on the psychological impact of screening and diagnosis of esophageal cancer (EC) is limited and unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, population\u2010based, prospective study was conducted in five high\u2010incidence regions in China from 2017 to 2020. The screened participants were diagnosed as healthy, esophagitis, low\u2010grade intraepithelial neoplasia (LGIN), high\u2010grade intraepithelial neoplasia (HGIN), or EC based on pathological biopsy. The psychological impact of the screening was assessed by comparing anxiety and depression symptoms at baseline and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1973 individuals were ultimately included, with an average follow\u2010up of 22.2\u00a0months. The prevalence of anxiety and depression symptoms in screened population at baseline was 14.3% and 18.4%. The prevalence of anxiety and depression symptoms of screeners at follow\u2010up declined (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The anxiety (RR [95% CI]: 0.37 [0.30\u20130.46]) and depression (0.29 [0.24\u20130.36]) of screeners weakened over time, but the anxiety and depression symptoms was continuous for patients with HGIN and patients with EC. Compared with the participants classified as normal, the RRs(95% CI) of anxiety and depression symptoms were 2.20 (1.10\u20134.30) and 2.03 (1.07\u20133.86) for the patients with HGIN and 2.30 (0.82\u20136.20) and 3.79 (01.71\u20138.43) for the patients with EC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The anxiety and depression symptoms of screeners weakened over time, except in patients with HGIN and EC, for whom it remained lasting and high. Psychological assistance and interventions are urgently needed for individuals who are ready for screening and for those diagnosed as having HGIN or EC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5404","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:45:22Z","timestamp":1669297522000},"page":"6294-6306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term anxiety and depression signatures of participants that received esophageal cancer screening: A multicenter population\u2010based cohort study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-5487","authenticated-orcid":false,"given":"Juan","family":"Zhu","sequence":"first","affiliation":[{"name":"National Central Cancer Registry, National Cancer Center\/National Clinical Research Center for Cancer \/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union 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