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Pink SWAN participants reported no cancer at SWAN enrollment and developed (BCS) or did not develop (controls) incident breast cancer after enrollment. Outcomes included: being sexually active or not, intercourse frequency, sexual desire, vaginal dryness, and pain with intercourse. Using longitudinal logistic regression, we compared BCS and controls on prevalence of sexual functioning outcomes with respect to years since diagnosis. In addition, we examined whether menopause transition stage, depressive symptoms, relationship satisfaction, vaginal dryness, or pain with intercourse modified the relation between breast cancer and sexual functioning outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusting for partner status, both BCS and controls reported similar declines over time in being sexually active, sexual intercourse frequency, and sexual desire. Among sexually active women, more BCS than controls consistently reported vaginal dryness with significant differences between 2 and 4\u2009years post\u2010diagnosis, and pain with intercourse, with statistically significant differences between 0.5\u2009years post\u2010diagnosis to 2\u2009years post\u2010diagnosis. Being post\u2010menopausal and reporting depressive symptoms were significant effect modifiers for pain with intercourse with both variables having positive and stronger associations with pain among the controls than among BCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Except for more reporting of vaginal dryness and pain with intercourse among BCS, negative changes in sexual function during mid\u2010life were similar in those with and without breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5433","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T09:24:25Z","timestamp":1669627465000},"page":"7356-7368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sexual functioning among breast cancer survivors and non\u2010cancer controls over 5\u2009years post diagnosis: Pink 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