{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:57:39Z","timestamp":1783133859878,"version":"3.54.6"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["20 0798 Fk"],"award-info":[{"award-number":["20 0798 Fk"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["FS\u20102021\u20100010"],"award-info":[{"award-number":["FS\u20102021\u20100010"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010810","name":"\u00d6gonfonden","doi-asserted-by":"publisher","award":["2021\u201004\u201028"],"award-info":[{"award-number":["2021\u201004\u201028"]}],"id":[{"id":"10.13039\/100010810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001725","name":"Royal Swedish Academy of Sciences","doi-asserted-by":"publisher","award":["ME2019\u20100036"],"award-info":[{"award-number":["ME2019\u20100036"]}],"id":[{"id":"10.13039\/501100001725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is debated if there are sex\u2010based differences in survival for patients with uveal melanoma. Previous observations of higher mortality for men in studies with &lt;10\u2010year follow\u2010up have not been replicated in studies with longer follow\u2010up. It is therefore hypothesized that women have a worse survival in later periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients diagnosed with primary uveal melanoma in Sweden between 1980 and 2017 were included (<jats:italic>n<\/jats:italic>\u00a0=\u00a02032). Survival differences between men and women in early (&lt;10\u2009years from diagnosis) and late (\u226510\u2009years) periods were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, there were no significant differences in mean patient age, tumor thickness, diameter, ciliary body involvement, primary treatment modality, or in American Joint Committee on Cancer (AJCC) T\u2010category between men and women. In total, 764 patients (425 women and 339 men) survived and were followed \u226510\u2009years. In this group, men were significantly younger, but there were no differences in baseline tumor thickness, diameter, ciliary body involvement, primary treatment, or AJCC T\u2010category. In competing risk analysis, women had higher incidence of uveal melanoma\u2010related mortality in the late period (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.036). In univariate Cox regression, male (HR 1.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.049) and female sex (HR 1.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.034) were significant predictors of uveal melanoma\u2010related mortality in the early and late periods, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with uveal melanoma have better survival in the first decade after diagnosis. Thereafter, female survivors are significantly older than men and have a higher incidence of uveal melanoma\u2010related mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5458","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T10:05:11Z","timestamp":1668765911000},"page":"6700-6710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>Sex\u2010based<\/scp> differences in early and late uveal melanoma\u2010related mortality"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-8911","authenticated-orcid":false,"given":"Gustav","family":"St\u00e5lhammar","sequence":"first","affiliation":[{"name":"Division of Eye and Vision, Department of Clinical Neuroscience St. Erik Eye Hospital, Karolinska Institutet  Stockholm Sweden"},{"name":"St. Erik Eye Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-317949"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-022-00082-y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000575"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz176"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2167"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103485"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2771"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31824d09a8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901001)66:7<1596::AID-CNCR2820660726>3.0.CO;2-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.208"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-306810"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.272"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28625"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20866"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.040"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10365"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20077"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.6534"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328353ef30"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.07.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497186"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.12.1684"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0538"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.12.024"},{"key":"e_1_2_10_26_1","first-page":"2579","article-title":"Incidence of uveal melanoma in Sweden from 1960 to 1998","volume":"43","author":"Bergman L","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0081"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-313419"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315722"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68232-7"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88390-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705727"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11269"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023525"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.3.31"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.77"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000200"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.51"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-14-42"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.7.939"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(94)90059-0"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514650"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.07.003"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512174"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.02.017"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194472"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90736-9"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03851-9"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31470-3"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)77914-0"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2523"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.2986"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.023"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14847"},{"key":"e_1_2_10_55_1","first-page":"bjophthalmol\u201020","article-title":"Incidence and mortality of uveal melanoma in Australia (1982\u20102014)","author":"Beasley AB","year":"2021","journal-title":"Br J Ophthalmol"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5458","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.5458","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:03:25Z","timestamp":1698653005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/cam4.5458"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5458","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,18]]},"assertion":[{"value":"2022-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}