{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:52:57Z","timestamp":1792252377726,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, the combination of venetoclax plus a hypomethylating agent (HMA; azacitidine ordecitabine) or low\u2010dose cytarabine (LDAC) showed promise in Phase III trials in previously untreated AML. In France at the time of this study, venetoclax was not yet approved for AML and there were therefore no formal usage recommendations. Here we report the first study in a French cohort that assessed venetoclax in combination with existing treatments for AML under real\u2010life conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective, real\u2010life study collected data on venetoclax use and management in a French cohort with acute myeloid leukemia (AML) ineligible for intensive chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Of 118 patients, 81 were in second line\/beyond (71.6% also hypomethylating agent [HMA]; 23.5% lowdose cytarabine [LDAC]) and 37 in first line. For venetoclax initiation, 57.3% underwent ramp up and 74.6% were hospitalized. Median venetoclax duration was 2.5 months (range 0.03\u201016.2). With all treatment lines and regimens, most common grade 3\/4 adverse events were hematologic (overall 96.4% of patients) and infections (57.1%). Dosage adjustments for drug interactions and safety varied between centers. In second\u2010line\/beyond, median progression\u2010free survival was 4.0 months (95% confidence interval [CI] 2.7\u201012.8) with venetoclax\u2010HMA and 3.4 months (1.3\u20108.9) with venetoclax\u2010LDAC; overall response rate was 51.9% and 41.2%, respectively. Thus, we showed that venetoclax\u2010based treatment yields promising findings in patients with AML, but to address treatment complexity, practice harmonization is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5459","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T04:39:38Z","timestamp":1670560778000},"page":"7175-7181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Retrospective, real\u2010life study of venetoclax plus azacitidine or low\u2010dose cytarabine in French patients with acute myeloid leukemia ineligible for intensive chemotherapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Louise","family":"Laloi","sequence":"first","affiliation":[{"name":"Department of Pharmacy Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha Chaumard","family":"Billotey","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-3548","authenticated-orcid":false,"given":"Pierre\u2010Yves","family":"Dumas","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciane","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Villate","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lestine","family":"Simand","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Fornecker","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-5784","authenticated-orcid":false,"given":"Florent","family":"Puisset","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Institut Universitaire du Cancer Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bertoli","sequence":"additional","affiliation":[{"name":"Department of Hematology Institut Universitaire du Cancer Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion Boissard","family":"Simonet","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-6164","authenticated-orcid":false,"given":"Kamel","family":"Laribi","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Le Mans  Le Mans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyhia","family":"Houyou","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Hospital of Troyes  Troyes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Santagostino","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Troyes  Troyes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4384-5551","authenticated-orcid":false,"given":"Claire","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle Roth","family":"Guepin","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Guerineau","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Hospital of Mont de Marsan  Mont de Marsan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Mont de Marsan  Mont de Marsan 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Cartet","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hospital of Bourgoin\u2010Jallieu  Bourgoin\u2010Jallieu France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Rocher","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Bourgoin\u2010Jallieu  Bourgoin\u2010Jallieu France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lachenal","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Bourgoin\u2010Jallieu  Bourgoin\u2010Jallieu France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Morisset","sequence":"additional","affiliation":[{"name":"Independent Biostatistician  P\u00e9rouges 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