{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:25:50Z","timestamp":1782509150848,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute myeloid leukemia (AML) patients with a Fms\u2010like tyrosine kinase 3 (FLT3) mutation have a high incidence of relapse despite allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) and a subsequent poor prognosis. FLT3 inhibitors (FLT3i) have been suggested to reduce the post\u2010transplant relapse risk in recent studies. As more evidence is accumulated, we perform the present meta\u2010analysis to assess the efficacy and safety of FLT3i as post\u2010transplant maintenance therapy in AML patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search was performed in public databases from inception to December 31, 2021. Overall survival (OS), relapse\u2010free survival (RFS), cumulative incidence of relapse (CIR), non\u2010relapse mortality (NRM), graft\u2010versus\u2010host disease (GVHD) and adverse events were compared between FLT3i and control groups. Pooled hazard ratio (HR) or relative risk (RR) with corresponding 95% confidence interval (CI) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 12 eligible studies with 2282 FLT3\u2010mutated AML patients who had received HSCT. There was no between\u2010study heterogeneity and a fix\u2010effect model was used. Post\u2010transplant FLT3i maintenance significantly prolonged OS (HR\u00a0=\u00a00.41, 95%CI: 0.32\u20130.52, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and RFS (HR\u00a0=\u00a00.39, 95%CI 0.31\u20130.50, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and reduced CIR (HR\u00a0=\u00a00.31, 95%CI 0.20\u20130.46, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as compared with control. There were no significant risk differences in NRM (RR\u00a0=\u00a00.69, 95%CI 0.41\u20131.17, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.169), acute GVHD (RR\u00a0=\u00a01.17, 95%CI 0.93\u20131.47, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.175), chronic GVHD (RR\u00a0=\u00a01.31, 95%CI 0.91\u20131.39, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.276) and grade\u2009\u22653 adverse events between both groups, except for skin toxicity (RR\u00a0=\u00a05.86, 95%CI 1.34\u201325.57, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Post\u2010transplant FLT3i maintenance can improve survival and reduce relapse in FLT3\u2010mutated AML patients and is tolerable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5480","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T06:25:55Z","timestamp":1669098355000},"page":"6877-6888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<scp>FLT3<\/scp> inhibitors as maintenance therapy post allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with <scp>FLT3<\/scp> mutations: A meta\u2010analysis"],"prefix":"10.1002","volume":"12","author":[{"given":"Xinhong","family":"Fei","sequence":"first","affiliation":[{"name":"Department of Hematology Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Aerospace Center Hospital  Beijing 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