{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:48:46Z","timestamp":1760647726934,"version":"3.40.5"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010878","name":"AbbVie Biotherapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000130","name":"National Center for Chronic Disease Prevention and Health Promotion","doi-asserted-by":"publisher","award":["NU58DP006318"],"award-info":[{"award-number":["NU58DP006318"]}],"id":[{"id":"10.13039\/100000130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of markers has stimulated the development of more appropriate targeted therapies for chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). We assessed the use and prevalence of biological and genetic markers of CLL and AML in the homogeneous Hispanic population of Puerto Rico.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the Puerto Rico CLL\/AML Population\u2010Based Registry, which combines information from linked databases. Logistic regression models were used to examine factors associated with biological and genetic testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 926 patients 18\u2009years or older diagnosed with CLL (<jats:italic>n<\/jats:italic>\u00a0=\u00a0518) and AML (<jats:italic>n<\/jats:italic>\u00a0=\u00a0408) during 2011\u20132015 were included in this analysis. Cytogenetic testing (FISH) was reported for 441 (85.1%) of the CLL patients; of those, 24.0% had the presence of trisomy 12, 9.5% carried deletion 11q, 50.3% carried deletion 13q, and 6.3% carried deletion 17p. Regarding AML, patients with cytogenetics and molecular tests were considered to determine the risk category (254 patients), of which 39.8% showed poor or adverse risk. Older age and having more comorbidities among patients with CLL were associated with a lower likelihood of receiving a FISH test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although prognostic genetic testing is required for treatment decisions, the amount of testing in this Hispanic cohort is far from ideal. Furthermore, some tests were not homogeneously distributed in the population, which requires further exploration and monitoring. This study contributes to the field by informing the medical community about the use and prevalence of biological and genetic markers of CLL and AML. Similarly, it has the potential to improve the management of CLL and AML through benchmarking.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5482","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T07:10:12Z","timestamp":1669446612000},"page":"6889-6901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patterns of use of biological and genetic markers for chronic lymphocytic leukemia and acute myeloid leukemia in Puerto Rico"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-9947","authenticated-orcid":false,"given":"Karen J.","family":"Ortiz\u2010Ortiz","sequence":"first","affiliation":[{"name":"Division of Cancer Control and Population Sciences University of Puerto Rico Comprehensive Cancer Center  San Juan Puerto Rico"},{"name":"Puerto Rico Central Cancer Registry University of Puerto Rico, Comprehensive Cancer Center  San Juan Puerto Rico"},{"name":"Department of Health Services Administration, Graduate School of Public Health, Medical Sciences Campus University of Puerto Rico  San\u00a0Juan Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos R.","family":"Torres\u2010Cintr\u00f3n","sequence":"additional","affiliation":[{"name":"Puerto Rico Central Cancer Registry University of Puerto Rico, Comprehensive Cancer Center  San Juan Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonatiuh","family":"Su\u00e1rez Ramos","sequence":"additional","affiliation":[{"name":"Puerto Rico Central Cancer Registry University of Puerto Rico, Comprehensive Cancer Center  San Juan Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-7656","authenticated-orcid":false,"given":"Maira A.","family":"Casta\u00f1eda\u2010Avila","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Cotto Santana","sequence":"additional","affiliation":[{"name":"Auxilio Mutuo Hospital  San Juan Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Tortolero\u2010Luna","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences University of Puerto Rico Comprehensive Cancer Center  San Juan Puerto Rico"},{"name":"Puerto Rico Central Cancer Registry University of Puerto Rico, Comprehensive Cancer Center  San Juan Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.8421"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1578152"},{"volume-title":"Cancer in Puerto Rico, 2012\u20132016","year":"2020","author":"Torres\u2010Cintr\u00f3n CR","key":"e_1_2_11_4_1"},{"volume-title":"American Community Survey 5\u2010Year Estimates, 2015\u20102019","year":"2020","author":"US Census Bureau","key":"e_1_2_11_5_1"},{"key":"e_1_2_11_6_1","unstructured":"HinojosaJ Mel\u00e9ndezE SeverinoKPopulation Decline and School Closure in Puerto Rico. (2019)."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30029-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.783913"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-015-0242-7"},{"key":"e_1_2_11_10_1","first-page":"329","article-title":"Acute myeloid leukemia\u2014genetic alterations and their clinical prognosis","volume":"11","author":"Lagunas\u2010Rangel FA","year":"2017","journal-title":"Int J Hematol Stem Cell Res"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404935"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.7184"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0203-RA"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00271-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00256-0"},{"key":"e_1_2_11_16_1","first-page":"1","article-title":"Recent progress of prognostic biomarkers and risk scoring systems in chronic lymphocytic leukemia","volume":"8","author":"Yun X","year":"2020","journal-title":"BMC"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.08.005"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31738"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.11.010"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194415"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.167"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481502204s03"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw547"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/BLCTT.S47649"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481502204s04"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432602"},{"key":"e_1_2_11_27_1","first-page":"185","article-title":"Chronic lymphocytic leukemia\/small lymphocytic lymphoma, version 4.2020, NCCN clinical practice guidelines in oncology","volume":"18","author":"Wierda WG","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.08.005"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.190132"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402537"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2008.08.019"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14332"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186684"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.207399"},{"key":"e_1_2_11_35_1","first-page":"1742","article-title":"IGHV mutation status and outcome in CLL patients treated with chemoimmunotherapy: a Nationwide analysis","volume":"130","author":"Curovic Rotbain EC","year":"2017","journal-title":"Blood"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24808"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.329"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24493"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.187583"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.8762"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-659144"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112304"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1752"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-5-5"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-009-0011-8"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.3762"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1106-9"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-019-0173-z"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2322"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0772"},{"issue":"9","key":"e_1_2_11_51_1","first-page":"1082","article-title":"The influence of age on prognosis of de novo acute myeloid leukemia differs according to cytogenetic subgroups","volume":"89","author":"Schoch C","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402029"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2014.10"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.484"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0736-x"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.0779"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.049270"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.37"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2016.08.005"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.205013"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6962379"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.298"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.904"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200382"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0055-7"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-325050"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.5482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.5482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:58:18Z","timestamp":1698652698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.5482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/cam4.5482"],"URL":"https:\/\/doi.org\/10.1002\/cam4.5482","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2022,11,25]]},"assertion":[{"value":"2022-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}