{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:39:01Z","timestamp":1747147141508,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T00:00:00Z","timestamp":1670112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the diagnostic accuracy of ultrasound measurement of optic nerve sheath diameter (ONSD) and optic disc height (ODH) in detecting intracranial hypertension in non\u2010small\u2010cell lung cancer (NSCLC) patients with leptomeningeal metastases (LM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010two patients with NSCLC\u2010LM and 65 patients with NSCLC were enrolled. The ONSD, ODH, eyeball transverse diameter (ETD), and eyeball vertical diameter (EVD) were measured by ultrasound. Subsequently, lumbar puncture was performed in NSCLC\u2010LM patients to measure cerebrospinal fluid pressure (CSFP), and intrathecal chemotherapy was regularly implemented. Pearson's correlation analysis was used to analyze the relationship between CSFP and ultrasound findings. The diagnostic accuracy of ONSD, ODH, and combined ONSD and ODH was evaluated by receiver operating characteristic (ROC) curve analysis and the corresponding area under the ROC curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ONSD, ODH, ONSD\/ETD, and ONSD\/EVD values were higher in the NSCLC\u2010LM group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The ONSD, ODH, ONSD\/ETD, and ONSD\/EVD values were all elevated in the abnormally elevated CSFP group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). ONSD, ODH, ONSD\/ETD, and ONSD\/EVD were positively correlated with CSFP (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.531, 0.383, 0.534, and 0.535, all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The AUCs for ONSD, ODH, ONSD\/ETD, and ONSD\/EVD to detect CSFP &gt;280\u2009mmH2O were 0.787 (95% CI: 0.64\u20130.93, sensitivity 68.75%, specificity 91.07%), 0.885 (95% CI: 0.81\u20130.96, sensitivity 100%, specificity 69.64%), 0.765 (95% CI: 0.64\u20130.89, sensitivity 81.25%, specificity 64.29%), and 0.788 (95% CI: 0.64\u20130.93, sensitivity 56.25%, specificity 91.07%), respectively. When ONSD was combined with ODH, the AUC was 0.913 (95% CI: 0.83\u20130.99, sensitivity 87.85%, specificity 85.70%). Furthermore, intrathecal chemotherapy was associated with a downtrend in CSFP and ultrasound findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are important advantages of using bedside ultrasonography for detecting elevated CSFP in NSCLC\u2010LM patients. Further research should be performed to evaluate the clinical significance of an enlarged ONSD and increased ODH in NSCLC\u2010LM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5484","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T06:12:46Z","timestamp":1670220766000},"page":"6913-6923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bedside ocular ultrasonography for diagnosing increased intracranial pressure in patients with leptomeningeal metastases from non\u2010small\u2010cell lung cancer"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7105-9494","authenticated-orcid":false,"given":"Cheng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Geriatric Oncology Nanjing Drum Tower Hospital Affiliated of Nanjing University Medical School  Nanjing 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Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Oncology Nanjing Drum Tower Hospital Affiliated of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingmin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Oncology Nanjing Drum Tower Hospital Affiliated of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aibin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Geriatric Oncology Nanjing Drum Tower Hospital Affiliated of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound 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