{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:11:47Z","timestamp":1785190307887,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019A1515010742"],"award-info":[{"award-number":["2019A1515010742"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stomach hemorrhage and perforation are very severe and common complications in patients with primary gastric diffuse large B\u2010cell lymphoma (PG\u2010DLBCL) during treatment with immunochemotherapy. However, no relevant clinical studies have been performed on the prevention of these serious complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with PG\u2010DLBCL were enrolled in this retrospective study. The prevention group received standard rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R\u2010CHOP) treatment without prednisone combined with antacids and anti\u2010Helicobacter pylori (Hp) therapy. These patients received R\u2010CHOP\u2010based treatment until the complete recovery of gastric ulcers, as proven by gastroscopy. The control group received a standard R\u2010CHOP regimen. Toxicity and survival were the main endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 52 patients received preventative treatment, while 146 patients did not. Among patients with stage I, II\u20101, and II\u20102 disease, the prevention group had a lower rate of hemorrhage and perforation (0\/40) than the control group (10\/78, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.044). At a median follow\u2010up time of 25\u2009months, the 5\u2010year event\u2010free survival (EFS) rates were 97.1% in the prevention group and 66.1% in the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.025), and the 5\u2010year overall survival (OS) rates were 100% and 72.0%, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.021). However, the differences in the 5\u2010year EFS and OS of patients with disseminated disease were not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preventative treatment can decrease the risk of hemorrhage and perforation in patients with localized PG\u2010DLBCL during immunochemotherapy, leading to better EFS and OS in these patients. However, preventative treatment failed to reduce the risk of gastric hemorrhage and perforation and did not improve survival (EFS and OS) in advanced\u2010stage patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5486","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T10:07:36Z","timestamp":1673258856000},"page":"6924-6934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A study on the prevention of hemorrhage and perforation in patients with primary gastric diffuse large\u2010B cell lymphoma during treatment with immunochemotherapy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-7145","authenticated-orcid":false,"given":"Limei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in Southern China, and Collaborative Innovation Center of Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in Southern China, and Collaborative Innovation Center of Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in Southern China, and Collaborative Innovation Center of Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in Southern China, and Collaborative 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