{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:12:34Z","timestamp":1790795554388,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172776"],"award-info":[{"award-number":["82172776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["19ZXDBSY00060"],"award-info":[{"award-number":["19ZXDBSY00060"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Poor prognosis is linked to peripheral blood levels of preoperative platelet\u2010lymphocyte ratio (PLR) and neutrophil\u2010lymphocyte ratio (NLR) in many advanced cancers. Nevertheless, whether the correlation exists in resected early\u2010stage cases with non\u2010small cell lung cancer (NSCLC) stays controversial. Consequently, we performed a meta\u2010analysis to explore the preoperative NLR and PLR's prognostic significance in early\u2010stage patients with NSCLC undergoing curative surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relevant studies that validated the link between preoperative NLR or PLR and survival results were found via the proceeding databases: PubMed, Embase, Cochrane Library, and Web of Science. The merged 95% confidence interval (CI) and hazard ratio (HR) was employed to validate the link between the NLR or PLR's index and overall survival (OS) and disease\u2010free survival (DFS) in resected NSCLC cases. We used sensitivity and subgroup analyses to assess the studies' heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An overall of 21 studies were attributed to the meta\u2010analysis. The findings indicated that great preoperative NLR was considerably correlated with poor DFS (HR\u00a0=\u00a01.58, 95% CI: 1.37\u20131.82, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and poor OS (HR\u00a0=\u00a01.51, 95% CI: 1.33\u20131.72, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), respectively. Subgroup analyses were in line with the pooled findings. In aspect of PLR, raised PLR was indicative of inferior DFS (HR\u00a0=\u00a01.28, 95% CI: 1.04\u20131.58, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) and OS (HR\u00a0=\u00a01.37, 95% CI: 1.18\u20131.60, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the subgroup analyses between PLR and DFS, only subgroups with a sample size &lt;300 (HR\u00a0=\u00a01.67, 95% CI: 1.15\u20132.43, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) and TNM staging of mixed (I\u2010II) (HR\u00a0=\u00a01.47, 95% CI: 1.04\u20132.07, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.028) showed that the link between high PLR and poor DFS was significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative elevated NLR and PLR may act as prognostic biomarkers in resected early\u2010stage NSCLC cases and are therefore valuable for guiding postoperative adjuvant treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5505","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T16:32:56Z","timestamp":1670517176000},"page":"7065-7076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical significance of preoperative neutrophil\u2010lymphocyte ratio and platelet\u2010lymphocyte ratio in the prognosis of resected early\u2010stage patients with non\u2010small cell lung cancer: A meta\u2010analysis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-6351","authenticated-orcid":false,"given":"Weibo","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Lung Cancer Surgery Lung Cancer Institute, Tianjin Medical University General Hospital  Tianjin China"},{"name":"Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer Institute, Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Lung Cancer Surgery Lung Cancer Institute, Tianjin Medical University General Hospital  Tianjin China"},{"name":"Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer Institute, Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Lung Cancer Surgery Lung Cancer Institute, Tianjin Medical University General Hospital  Tianjin China"},{"name":"Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer Institute, Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Lung Cancer Surgery Lung Cancer Institute, Tianjin Medical University General Hospital  Tianjin China"},{"name":"Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer Institute, Tianjin Medical University General Hospital  Tianjin 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