{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:58:57Z","timestamp":1776416337751,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical evidence of immune checkpoint inhibitors combined with antiangiogenic drugs in patients with advanced non\u2010small cell lung cancer (NSCLC) was limited. Recombinant human endostatin (rh\u2010endostatin), an antiangiogenic drug, and camrelizumab, an anti\u2010PD\u20101 antibody, have been approved for the treatment of advanced NSCLC in China. This study aimed to investigate the efficacy and safety of rh\u2010endostatin plus camrelizumab and chemotherapy in the treatment of advanced NSCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible patients were enrolled and received camrelizumab (200\u2009mg, day 1) every 3\u2009weeks and continuous intravenous infusion of rh\u2010endostatin (70\u2009mg\/day, days 1\u20133) and cisplatin combined with pemetrexed (for adenocarcinoma) or paclitaxel (for NSCLC other than adenocarcinoma) every 3\u2009weeks. Primary endpoint was progression\u2010free survival (PFS). Secondary endpoints were objective response rate (ORR), disease control rate (DCR), overall survival (OS), and safety profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 27 patients were included, and 25 patients were eligible for efficacy evaluation. For these 25 patients, ORR was 48.15% (13\/27) and DCR was 85.19% (23\/27). With a median follow\u2010up of 10.37\u2009months, the median PFS was 8.9 (95% CI: 4.23\u201313.57) months. Median OS was not reached. Overall, 96.3% of patients experienced at least one treatment\u2010related adverse event, and grade 3 TRAEs occurred in 9 (33.3%) patients. No unexpected AEs were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rh\u2010endostatin plus camrelizumab and chemotherapy showed favorable efficacy and safety profile in patients with advanced NSCLC, representing a promising treatment regimen for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5526","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T05:38:45Z","timestamp":1670650725000},"page":"7724-7733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Rh\u2010endostatin plus camrelizumab and chemotherapy in first\u2010line treatment of advanced non\u2010small cell lung cancer: A multicenter retrospective study"],"prefix":"10.1002","volume":"12","author":[{"given":"Xingxiang","family":"Pu","sequence":"first","affiliation":[{"name":"Department of Thoracic Medical Oncology, Hunan Cancer Hospital\/the Affiliated Cancer Hospital 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