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This study focused on BC risk for women with type 2 diabetes mellitus (T2DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two separate meta\u2010analyses were conducted (1) to estimate the relative risk (RR) of BC for women with T2DM and (2) to evaluate the risk of BC for women with T2DM associated with the use of metformin, a common diabetes treatment. In addition, subgroup analyses adjusting for obesity as measured by body mass index (BMI) and menopausal status were also performed. Studies were identified via PubMed\/Scopus database and manual search through April 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30 and 15 studies were included in the first and second meta\u2010analyses, respectively. The summary RR of BC for women with T2DM was 1.15 (95% confidence interval [CI], 1.09\u20131.21). The subgroup analyses adjusting BMI and adjusting BMI and menopause resulted in a summary RR of 1.22 (95% CI, 1.15\u20131.30) and 1.20 (95% CI, 1.05\u20131.36), respectively. For women with T2DM, the summary RR of BC was 0.82 (95% CI, 0.60\u20131.12) for metformin users compared with nonmetformin users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with T2DM were more likely to be diagnosed with BC and this association was strengthened by adjusting for BMI and menopausal status. No statistically significant reduction of BC risk was observed among metformin users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Impact<\/jats:title><jats:p>These two meta\u2010analyses can inform decision\u2010making for women with type 2 diabetes regarding their use of metformin and the use of screening mammography for early detection of breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5545","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T10:05:43Z","timestamp":1671444343000},"page":"11703-11718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Breast cancer risk for women with diabetes and the impact of metformin: A meta\u2010analysis"],"prefix":"10.1002","volume":"12","author":[{"given":"Yifan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Industrial and Systems Engineering University of Wisconsin\u2010Madison  Madison Wisconsin 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