{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:54:01Z","timestamp":1787882041641,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cisplatin, a first\u2010generation platinum agent, is used for managing various cancers and is associated with dose\u2010dependent side effects of hearing impairment and tinnitus. However, the safety of high\u2010dose cisplatin in hearing impairment, has not been fully investigated in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed pure\u2010tone threshold audiometry before and every 3\u20134\u2009weeks after chemotherapy for patients receiving cisplatin\u2010containing chemotherapy between April 2015 and October 2017 at Kobe Minimally Invasive Cancer Center. Hearing impairment was evaluated prospectively using the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 100 patients and analyzed 96 patients for whom post\u2010chemotherapy audiometry could be performed. The median patient age was 65\u2009years, and most patients were male (75). The cancer types were as follows: esophageal, 36; head and neck, 35; lung, 23; and gastric, 2. Cisplatin monotherapy and combination therapy were administered to 33 and 63 patients, respectively. A single cisplatin dose was 60\u2013100\u2009mg\/m<jats:sup>2<\/jats:sup>; the median number of doses and total dose were 3 and 240\u2009mg\/m<jats:sup>2<\/jats:sup>, respectively. Additionally, 78 and 18 patients were treated with concurrent chemoradiotherapy and chemotherapy alone, respectively. Twenty\u2010seven patients had grade 2 or higher hearing impairment. Furthermore, the prevalence was significantly higher in patients receiving a total dose of \u2265300\u2009mg\/m<jats:sup>2<\/jats:sup>. Twenty and 32 patients were aware of deafness and tinnitus, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No patient discontinued treatment owing to hearing impairment. The total cisplatin dose was considered related to post\u2010treatment hearing impairment frequency in Japanese patients. However, routine audiometric monitoring is recommended during high\u2010dose cisplatin\u2010based chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.5565","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T06:19:25Z","timestamp":1672035565000},"page":"7904-7910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk factors associated with cisplatin\u2010induced ototoxicity in Japanese patients with solid tumors"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-3445","authenticated-orcid":false,"given":"Hideaki","family":"Okada","sequence":"first","affiliation":[{"name":"Division of Medical Oncology Kobe Minimally Invasive Cancer Center  Kobe 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